Details of Disease | DrugMAP

General Information of Disease (ID: DISFH7MK)

Disease Name	Obsolete Glanzmann's thrombasthenia
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DISFH7MK: Obsolete Glanzmann's thrombasthenia

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ITGB3	TTJA1ZO	Supportive	Autosomal recessive	[1]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ITGB3	OTWCK1K6	Supportive	Autosomal recessive	[1]
ITGA2B	OT4Y17PY	Definitive	Autosomal recessive	[2]
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References

1	Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood. 2011 Dec 1;118(23):5996-6005. doi: 10.1182/blood-2011-07-365635. Epub 2011 Sep 13.
2	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.