Details of Disease

General Information of Disease (ID: DISFL6YG)

• Disease Name: Type III hypersensitivity disease
• Synonyms: hypersensitivity reaction type III disease; type III hypersensitivity; type 3 hypersensitivity reaction; immune complex disease; type III hypersensitivity reaction; disorder of type III hypersensitivity
• Definition: Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa.
• Disease Hierarchy:
  DISORMTM: Autoimmune disease
  DISWD40R: Disease
  DISEDL2I: Hypersensitivity
  DISFL6YG: Type III hypersensitivity disease
• Disease Identifiers:
  MONDO ID: MONDO_0007004
  MESH ID: D007105
  UMLS CUI: C0020951
  MedGen ID: 7021

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MASP2	TTR01E9	Strong	Biomarker	[1]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C1QA	OT6XKVVA	Strong	Biomarker	[2]
CD72	OTPOJID2	Strong	Biomarker	[3]

References

• [1] Inherited deficiency of mannan-binding lectin-associated serine protease 2.N Engl J Med. 2003 Aug 7;349(6):554-60. doi: 10.1056/NEJMoa022836.
• [2] Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family.Kidney Int. 1996 Aug;50(2):635-42. doi: 10.1038/ki.1996.359.
• [3] CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.J Dermatol Sci. 2019 Jul;95(1):36-43. doi: 10.1016/j.jdermsci.2019.06.005. Epub 2019 Jun 20.