Details of Disease

Disease Name

Chronic HCV-1 infection

Disease Class

1E50-1E51: Hepatitis virus infection

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISFN8ZV: Chronic HCV-1 infection

ICD-11

ICD-11: 1E51.1

ICD-10

ICD-10: B18.2

Expand ICD-11

'1E51.1

Expand ICD-10

'B18.2

Expand ICD-9

070.4,070.5,070.70

General Information of Disease (ID: DISFN8ZV)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Interferon Alfa-2a, Recombinant	DMUTZ8S	Approved	NA	[1]
Simeprevir	DMLUA9D	Approved	Small molecular drug	[2]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Single Tablet Regimen of sofosbuvir and ledipasvir	DMPYYIF	Phase 3	NA	[3]
GI-5005	DMMCEV0	Phase 2	NA	[4]
GS-5816	DMUIQUK	Phase 2	NA	[5]
GS-9451	DMF910Q	Phase 2	Small molecular drug	[6]
GS-9669	DMO1NMJ	Phase 2	Small molecular drug	[7]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7367).
3	Clinical pipeline report, company report or official report of Gilead.
4	ClinicalTrials.gov (NCT00606086) Safety and Efficacy of the Therapeutic Vaccine GI-5005 Combined With Pegylated Interferon Plus Ribavirin Standard of Care Therapy Versus Standard of Care Alone in Patients With Genotype 1 Chronic Hepatitis C Infection. U.S. National Institutes of Health.
5	ClinicalTrials.gov (NCT02336139) A Phase II Trial of Sofosbuvir (SOF) and GS-5816 for People With Chronic Hepatitis C Virus Infection and Recent Injection Drug Use. U.S. National Institutes of Health.
6	ClinicalTrials.gov (NCT01353248) GS 5885 Administered Concomitantly With GS-9451, Tegobuvir and Ribavirin (RBV) in Chronic Genotype 1 Hepatitis C Virus (HCV) Infection. U.S. National Institutes of Health.
7	ClinicalTrials.gov (NCT01260350) Open-Labeled Study of PSI-7977 and RBV With and Without PEG-IFN in Treatment-Naive Patients With HCV GT2 or GT3. U.S. National Institutes of Health.