General Information of Disease (ID: DISG024R)

Disease Name Cholecystitis
Synonyms
gallstone cholecystitis; acalculous cholecystitis; chronic cholecystitis; acute on chronic cholecystitis; acute cholecystitis; inflammation of gall bladder; gall bladder inflammation; acute and chronic cholecystitis
Definition An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones.
Disease Hierarchy
DISWD40R: Disease
DIS9U3YN: Cholangitis
DISA6W3T: Gallbladder disease
DISG024R: Cholecystitis
Disease Identifiers
MONDO ID
MONDO_0002155
MESH ID
D002764
UMLS CUI
C0008325
MedGen ID
920
HPO ID
HP:0001082
SNOMED CT ID
76581006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Doripenem DM9UCJK Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCB4 TTJUXV6 Strong Genetic Variation [2]
GLP2R TT1YWO5 Strong Genetic Variation [3]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SSBP2 OTYG1G80 Limited Posttranslational Modification [4]
AGA OTNWT1WB Strong Genetic Variation [5]
OPN1MW OTPJ7LX4 Strong Biomarker [6]
ABCG8 OTIJ76XW Definitive Altered Expression [7]
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References

1 Doripenem FDA Label
2 Diagnosis of monogenic liver diseases in childhood by next-generation sequencing.Clin Genet. 2018 Mar;93(3):665-670. doi: 10.1111/cge.13120. Epub 2017 Dec 12.
3 New Avenues in the Regulation of Gallbladder Motility-Implications for the Use of Glucagon-Like Peptide-Derived Drugs.J Clin Endocrinol Metab. 2019 Jul 1;104(7):2463-2472. doi: 10.1210/jc.2018-01008.
4 Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.Future Oncol. 2015;11(2):233-49. doi: 10.2217/fon.14.165. Epub 2014 Jul 28.
5 Small for gestational age as an independent risk factor for long-term pediatric gastrointestinal morbidity of the offspring().J Matern Fetal Neonatal Med. 2019 May;32(9):1407-1411. doi: 10.1080/14767058.2017.1406473. Epub 2017 Dec 4.
6 Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system.Surg Endosc. 2020 Oct;34(10):4549-4561. doi: 10.1007/s00464-019-07244-5. Epub 2019 Nov 15.
7 Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.Sci Rep. 2019 Jan 28;9(1):772. doi: 10.1038/s41598-018-35852-z.