General Information of Disease (ID: DISGENW9)

Disease Name Lactose intolerance
Synonyms lactase persistence; LM - lactose malabsorption; lactose intolerance (disease); lactose intolerance
Disease Class 5C61: Carbohydrate absorption/transport disorder
Disease Hierarchy
DISGMUVS: Malabsorption syndrome
DIS0W6QK: Nutritional disorder
DISV24X3: Carbohydrate metabolism disorder
DISGENW9: Lactose intolerance
ICD Code
ICD-11
ICD-11: 5C61.6
Expand ICD-11
'5C61.6
Expand ICD-10
'E73; 'E73.8; 'E73.9
Disease Identifiers
MONDO ID
MONDO_0100345
MESH ID
D007787
UMLS CUI
C0022951
MedGen ID
6001
HPO ID
HP:0004789
SNOMED CT ID
782415009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
RP-G28 DMWK213 Phase 2 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
LCT TTA0OSE Strong Genetic Variation [2]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DDX43 OTK1RYSK Limited Genetic Variation [3]
CSN2 OT22C0PD Strong Biomarker [4]
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References

1 ClinicalTrials.gov (NCT01113619) Effectiveness, Safety and Tolerability Study of RP-G28 for Symptoms Associated With Lactose Intolerance. U.S. National Institutes of Health.
2 Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants.J Bone Miner Metab. 2020 May;38(3):378-384. doi: 10.1007/s00774-019-01070-4. Epub 2019 Dec 4.
3 Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women.Eur J Clin Nutr. 2005 Oct;59(10):1105-11. doi: 10.1038/sj.ejcn.1602219.
4 Comparison of the impact of bovine milk -casein variants on digestive comfort in females self-reporting dairy intolerance: a randomized controlled trial.Am J Clin Nutr. 2020 Jan 1;111(1):149-160. doi: 10.1093/ajcn/nqz279.