Details of Disease

General Information of Disease (ID: DISH5078)

Disease Name Fibroma
Synonyms fibroma, benign; fibroma
Definition A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts.
Disease Hierarchy
:
DISH5078: Fibroma
Disease Identifiers
MONDO ID
MONDO_0005167
UMLS CUI
C0016045
MedGen ID
42016
HPO ID
HP:0010614
SNOMED CT ID
424568000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GRM1 TTVBPDM Limited Biomarker [1]
ANTXR2 TTOD34I Strong Biomarker [2]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
BRF1 OTQC6DMG Strong Biomarker [3]
CDC73 OT6JASZ1 Strong Biomarker [4]
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References

1 GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.Nat Genet. 2014 May;46(5):474-7. doi: 10.1038/ng.2927. Epub 2014 Mar 23.
2 Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct;73(4):957-66. doi: 10.1086/378781. Epub 2003 Sep 12.
3 Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.J Biol Chem. 2008 Jul 11;283(28):19184-91. doi: 10.1074/jbc.M802872200. Epub 2008 May 1.
4 Familial isolated hyperparathyroidism due to multiple adenomas associated with ossifying jaw fibroma and multiple uterine adenomyomatous polyps.Eur J Endocrinol. 1998 May;138(5):557-61. doi: 10.1530/eje.0.1380557.