Details of Disease

General Information of Disease (ID: DISHVC9B)

• Disease Name: Esophagitis
• Synonyms: acute esophagitis; oesophagus inflammation; inflammation of oesophagus; inflammation of esophagus; esophagus inflammation; esophagitis (disease); esophagitis
• Definition: An acute or chronic inflammatory disease affecting the esophageal wall.
• Disease Hierarchy:
  DISWD40R: Disease
  DIS5L3HQ: Esophageal disorder
  DIS184KT: Skin inflammation
  DISHVC9B: Esophagitis
• Disease Identifiers:
  MONDO ID: MONDO_0001409
  MESH ID: D004941
  UMLS CUI: C0014868
  MedGen ID: 4549
  HPO ID: HP:0100633
  SNOMED CT ID: 16761005

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PGA5	TTKZ864	Limited	Biomarker	[1]
TRPV1	TTMI6F5	Limited	Biomarker	[2]
ATP4A	TTF1QVM	Strong	Biomarker	[3]
FUT3	TTUPAD7	Strong	Genetic Variation	[4]
RPS6KB2	TTMVQXO	Strong	Genetic Variation	[5]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ATP12A	DT5NLZA	Strong	Biomarker	[3]

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADGRV1	OTLVXHHP	Strong	Genetic Variation	[6]
CCL26	OT2B7HR9	Strong	Altered Expression	[7]
CDX2	OTCG4TSY	Strong	Altered Expression	[8]
DEGS1	OT4WXPKW	Strong	Biomarker	[9]
DKK4	OTWCCVF6	Strong	Altered Expression	[10]
NOX5	OTHTH59G	Strong	Altered Expression	[11]
NPNT	OTFZAO1G	Strong	Genetic Variation	[4]
PLCE1	OTJISZOX	Strong	Altered Expression	[12]
PLCL1	OTJL2C79	Strong	Genetic Variation	[13]

References

• [1] c-Fos immunoreactivity in the brain after esophageal acid stimulation.Am J Med. 2003 Aug 18;115 Suppl 3A:31S-38S. doi: 10.1016/s0002-9343(03)00190-6.
• [2] Attenuation of acid induced oesophagitis in VR-1 deficient mice.Gut. 2006 Jan;55(1):34-40. doi: 10.1136/gut.2005.066795. Epub 2005 Aug 9.
• [3] Symptomatic exfoliative esophagitis induced by dabigatran.Rev Esp Enferm Dig. 2018 Nov;110(11):743-744. doi: 10.17235/reed.2018.5747/2018.
• [4] Poem Versus Laparoscopic Heller Myotomy in the Treatment of Esophageal Achalasia: A Case-Control Study from Two High Volume Centers Using the Propensity Score.J Gastrointest Surg. 2020 Mar;24(3):505-515. doi: 10.1007/s11605-019-04465-w. Epub 2019 Dec 17.
• [5] MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer.PLoS One. 2016 Mar 18;11(3):e0150467. doi: 10.1371/journal.pone.0150467. eCollection 2016.
• [6] What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center.Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13061. Epub 2017 Apr 9.
• [7] Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease.Hum Pathol. 2007 Dec;38(12):1744-53. doi: 10.1016/j.humpath.2007.05.008. Epub 2007 Sep 27.
• [8] Regulation of CDX2 expression in esophageal adenocarcinoma.Mol Carcinog. 2009 Oct;48(10):965-74. doi: 10.1002/mc.20549.
• [9] Decision analytic modeling for the economic analysis of proton radiotherapy for non-small cell lung cancer.Transl Lung Cancer Res. 2018 Apr;7(2):122-133. doi: 10.21037/tlcr.2018.03.27.
• [10] Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls.Am J Gastroenterol. 2006 Jul;101(7):1437-48. doi: 10.1111/j.1572-0241.2006.00584.x.
• [11] Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis.Gastroenterology. 2005 Nov;129(5):1675-85. doi: 10.1053/j.gastro.2005.09.008.
• [12] Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.Oncotarget. 2017 May 16;8(20):33285-33299. doi: 10.18632/oncotarget.16635.
• [13] A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.Mol Carcinog. 2013 Nov;52 Suppl 1(0 1):E80-6. doi: 10.1002/mc.22016. Epub 2013 Feb 6.