Details of Disease

General Information of Disease (ID: DISJ3EYJ)

Disease Name	Blastomycosis
Synonyms	infection by Blastomyces dermatitidis; Blastomyces dermatitidis infection; Blastomyces dermatitidis disease or disorder; Blastomyces dermatitidis caused disease or disorder; blastomycotic infection; North American blastomycosis; Chicago disease; Gilchrist's disease; Blastomyces dermatitidis infectious disease
Disease Class	1F22: Blastomycosis
Definition	Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body.The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant.
Disease Hierarchy	DISIP7GM: Primary systemic mycosis DISEM33Q: Infectious disease DISJ3EYJ: Blastomycosis
ICD Code	ICD-11 ICD-11: 1F22 ICD-9 ICD-9: 116 Expand ICD-11 '1F22 Expand ICD-10 'B40; 'B40.0; 'B40.1; 'B40.2; 'B40.3; 'B40.7; 'B40.8; 'B40.9 Expand ICD-9 116
Disease Identifiers	MONDO ID MONDO_0005672 MESH ID D001759 UMLS CUI C0005716 MedGen ID 597 SNOMED CT ID 69996000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Hydroxystilbamidine Isethionate	DMR5QS6	Approved	Small molecular drug	[2]
Itraconazole	DMCR1MV	Approved	Small molecular drug	[3]
Ketoconazole	DMPZI3Q	Approved	Small molecular drug	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ERC2	OTFEDI56	Strong	Biomarker	[5]
------------------------------------------------------------------------------------

References

1	Amphotericin B FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009166.
3	Itraconazole FDA Label
4	Ketoconazole FDA Label
5	Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis.Med Mycol. 2019 Oct 1;57(7):893-896. doi: 10.1093/mmy/myy137.