Details of Disease

General Information of Disease (ID: DISJPXO5)

• Disease Name: Wound healing
• Disease Class: EL8Y: Skin postprocedural disorder
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISJPXO5: Wound healing
• ICD Code: ICD-11: ICD-11: EL8Y

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 10 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ADCON-L	DM3R0BG	Approved	NA	[1]
ADCON-T/N	DMC0ND7	Approved	NA	[2]
Beriplast-P	DMEBY2D	Approved	NA	[1]
Dexpanthenol	DMUTSRW	Approved	Small molecular drug	[1]
Epidermal growth factor	DMVONE6	Approved	Small molecular drug	[3]
Fibrin Sealant	DMQRJ8L	Approved	NA	[4]
Fibrinolysin	DM9Q8SO	Approved	NA	[1]
Profezyme	DM0ZUBO	Approved	NA	[1]
TachoComb	DM6S0HB	Approved	NA	[1]
BIOVANCE	DMG0Y0T	Phase 4	NA	[5]

This Disease is Treated as An Indication in 9 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ACT-2	DMRP913	Phase 3	NA	[6]
Act1	DMXYRPO	Phase 3	Small molecular drug	[7]
Molgramostim	DM2TNJ1	Phase 3	NA	[8]
Evitar	DMT12ZN	Phase 2	NA	[9]
KUR-212	DMB4HCY	Phase 2	NA	[10]
HP-831-064	DMJ3VVP	Phase 1	NA	[11]
MD-920	DMR1086	Phase 1	NA	[12]
Recombinant human keratinocyte growth factor-2	DM1NM3F	Phase 1	NA	[13]
tiratricol	DMZO6CV	Clinical trial	Small molecular drug	[14]

This Disease is Treated as An Indication in 6 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ADCON(R)	DM4DAET	Discontinued in Phase 3	NA	[15]
Allox	DM588LC	Discontinued in Phase 2	NA	[16]
OcuNex	DMJ25BT	Discontinued in Phase 2	NA	[17]
ADCON-I	DM04DBF	Terminated	NA	[19]
LyphoDerm	DMTIMP5	Terminated	NA	[20]
SWT-02.100	DMFLJ33	Terminated	NA	[21]

This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SRD-285	DMN4QXV	Preclinical	NA	[18]

This Disease is Treated as An Indication in 15 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ADE-CRAN	DM23SAQ	Investigative	NA	[22]
ADE-LAM	DMXHW2U	Investigative	NA	[22]
AM-220	DMNWF9W	Investigative	NA	[22]
AXP-107-08	DMWH7VK	Investigative	NA	[22]
B-247	DMPVG8I	Investigative	NA	[22]
Choroid plexus cell-derived factors	DMI5MH8	Investigative	NA	[22]
CytoCor	DM20AEI	Investigative	NA	[22]
Endogenous human peptide LL-37	DMRVI0Q	Investigative	NA	[22]
HO/07/09	DMGWVGX	Investigative	NA	[22]
KUR-213	DMRFNUB	Investigative	NA	[22]
MD-921	DMC4WW4	Investigative	NA	[22]
PrLL-37	DMAX44W	Investigative	NA	[22]
Recombinant human fibrinogen	DM3NMQY	Investigative	NA	[22]
TRM-88	DMUSIKS	Investigative	NA	[22]
ZK-005	DMSNG16	Investigative	NA	[22]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008900)
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4916).
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020482)
• [5] ClinicalTrials.gov (NCT02521402) Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery.
• [6] ClinicalTrials.gov (NCT01229813) Avastin and Chemotherapy Followed by a KRAS Stratified Randomization to Maintenance Treatment for First Line Treatment of Metastatic Colorectal Cancer.. U.S. NationalInstitutes of Health.
• [7] ClinicalTrials.gov (NCT01816165) Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes. U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT02468908) Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037950)
• [10] ClinicalTrials.gov (NCT00471939) Safety and Efficacy of I-020502 in Meshed Skin Autografting. U.S. National Institutes of Health.
• [11] A review of tissue-engineered skin bioconstructs available for skin reconstruction. J R Soc Interface. 2010 Feb 6;7(43):229-58.
• [12] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022566)
• [13] Randomized phase I trial of recombinant human keratinocyte growth factor plus chemotherapy: potential role as mucosal protectant. J Clin Oncol. 2003 Apr 15;21(8):1452-8.
• [14] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2637).
• [15] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012114)
• [16] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017143)
• [17] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007146)
• [18] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028726)
• [19] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013166)
• [20] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019206)
• [21] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013761)
• [22] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.