Details of Disease

General Information of Disease (ID: DISKAXO0)

• Disease Name: Neoplasm of mature B-cells
• Synonyms: mature B-cell neoplasms; mature B-cell lymphocytic neoplasm; mature B-cell neoplasm
• Definition: A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).|Editor note: is a non-hodgkin in ONCOTREE
• Disease Hierarchy:
  DISVY326: B-cell neoplasm
  DISTBY9Z: Tumour
  DISKAXO0: Neoplasm of mature B-cells
• Disease Identifiers:
  MONDO ID: MONDO_0004949
  UMLS CUI: C1334633
  MedGen ID: 235305

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD86	TT53XHB	Strong	Genetic Variation	[1]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC14A2	DT8QC7K	Strong	Genetic Variation	[1]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CYBC1	OTGTH90I	Strong	Genetic Variation	[1]
GRAMD1B	OTCG1GX2	Strong	Genetic Variation	[2]
LPP	OT6TU8SE	Strong	Genetic Variation	[1]

References

• [1] Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.Am J Hum Genet. 2014 Oct 2;95(4):462-71. doi: 10.1016/j.ajhg.2014.09.004.
• [2] Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.Nat Genet. 2010 Aug;42(8):661-4. doi: 10.1038/ng.626. Epub 2010 Jul 18.