Details of Disease

General Information of Disease (ID: DISKBRLI)

Disease Name Squamous cell neoplasm
Synonyms
squamous cell tumour (qualifier value); squamous cell tumour; squamous cell tumor (qualifier value); squamous cell tumor; squamous cell neoplasm; epidermoid cell tumour; epidermoid cell tumor; epidermoid cell neoplasm
Definition A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example.
Disease Hierarchy
DIS0T594: Epithelial neoplasm
DISKBRLI: Squamous cell neoplasm
Disease Identifiers
MONDO ID
MONDO_0002532
MESH ID
D018307
UMLS CUI
C0206720
MedGen ID
60219
SNOMED CT ID
118286007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BRCA2 TTUARD6 Strong Biomarker [1]
CHEK2 TT9ABMF Strong Biomarker [1]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ATP2A3 OTFYDEES Strong Genetic Variation [2]
DVL1 OTD67RF1 Strong Altered Expression [3]
TP63 OT0WOOKQ Strong Biomarker [4]
TCEAL1 OTAPG2L5 Definitive Altered Expression [5]
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References

1 Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.Nat Genet. 2014 Jul;46(7):736-41. doi: 10.1038/ng.3002. Epub 2014 Jun 1.
2 Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.Prog Biophys Mol Biol. 2010 Sep;103(1):81-7. doi: 10.1016/j.pbiomolbio.2009.10.005. Epub 2009 Oct 17.
3 Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma.Oncol Rep. 2003 Sep-Oct;10(5):1219-23. doi: 10.3892/or.10.5.1219.
4 Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of Np63 protein. J Biol Chem. 2013 Feb 1;288(5):2907-13. doi: 10.1074/jbc.M112.428607. Epub 2012 Dec 27.
5 Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.Dis Esophagus. 2005;18(1):37-40. doi: 10.1111/j.1442-2050.2005.00432.x.