Details of Disease

General Information of Disease (ID: DISLG5PR)

Disease Name	Acute pyelonephritis
Synonyms	pyelonephritis, acute
Disease Class	GB51: Acute pyelonephritis
Definition	Sudden onset pyelonephritis.
Disease Hierarchy	DISAOX93: Pyelonephritis DISBV50J: Acute disease DISLG5PR: Acute pyelonephritis
ICD Code	ICD-11 ICD-11: GB51
Disease Identifiers	MONDO ID MONDO_0003529 UMLS CUI C0520575 MedGen ID 636072 SNOMED CT ID 36689008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benapenem	DMUBTMF	Phase 2/3	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CXCR1	TTMWT8Z	Strong	Genetic Variation	[2]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AMBP	OTLU8GU8	Strong	Biomarker	[3]
MRPS30	OTDXIAGG	Strong	Genetic Variation	[4]
MTPAP	OT6HQ02S	Strong	Genetic Variation	[4]
PAPOLA	OTPHD65D	Strong	Genetic Variation	[4]
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References

1	ClinicalTrials.gov (NCT04505683) A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP). U.S. National Institutes of Health.
2	Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
3	Discrimination of culture negative pyelonephritis in children with suspected febrile urinary tract infection and negative urine culture results.J Microbiol Immunol Infect. 2019 Aug;52(4):598-603. doi: 10.1016/j.jmii.2017.09.005. Epub 2017 Oct 25.
4	Sequence microdiversity at the ribosomal RNA operons of Escherichia coli pyelonephritogenic strains.Clin Microbiol Infect. 2001 Jul;7(7):345-51. doi: 10.1046/j.1198-743x.2001.00260.x.