Details of Disease

General Information of Disease (ID: DISLRPYJ)

Disease Name Euthyroid goiter
Synonyms nontoxic goiter; non-toxic simple goitre; non-toxic simple goiter; non-toxic goitre; non-toxic goiter; goiter, non-toxic; euthyroid goitre; euthyroid goiter; Nodule-thyroid, non tox
Disease Class 5A01: Euthyroid goiter
Definition Sporadic enlargement of the thyroid gland that is not associated with changes in thyroid function or malignancy.
Disease Hierarchy
DISLCGI6: Goiter
DISLRPYJ: Euthyroid goiter
ICD Code
ICD-11
ICD-11: 5A01.1
Disease Identifiers
MONDO ID
MONDO_0001658
MESH ID
C562732
UMLS CUI
C0221777
OMIM ID
138800
MedGen ID
113172
HPO ID
HP:0009798
Orphanet ID
276399

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial
Drug Name Drug ID Highest Status Drug Type REF
Triiodothyronine DM14NKM Phase 2 Trial Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AMELX OTIN26MM Strong Biomarker [2]
MLXIP OT30UNI7 Strong Biomarker [3]
PELI1 OTMLBCLC Strong Genetic Variation [4]
PRDM6 OTKY12D9 Strong Genetic Variation [4]
TG OT3ELHIJ Definitive Genetic Variation [5]
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References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076923.
2 Radioiodine therapy of benign thyroid-disorders.Nuklearmedizin. 2017;56(5):171-176. doi: 10.3413/Nukmed-0875-17-01. Epub 2018 Jan 4.
3 The adaptation of TSH secretion to autonomy in non-toxic goiter may be based-on active regulation of set-point and sensitivity of central TSH-receptors, perhaps by the microRNA (MIR) gene.Med Hypotheses. 2006;67(3):588-91. doi: 10.1016/j.mehy.2005.12.049. Epub 2006 May 5.
4 Analysis of correlation between the process of thyroid fibrosis and TGFB1 gene expression level in fine-needle aspiration biopsy (FNAB) thyroid specimens collected from patients with Hashimoto's thyroiditis and non-toxic goitre.Exp Clin Endocrinol Diabetes. 2010 Jul;118(7):420-6. doi: 10.1055/s-0029-1225614. Epub 2010 Feb 26.
5 Haplotype analysis reveals founder effects of thyroglobulin gene mutations C1058R and C1977S in Japan.J Clin Endocrinol Metab. 2006 Aug;91(8):3100-4. doi: 10.1210/jc.2005-2702. Epub 2006 May 23.