Details of Disease

General Information of Disease (ID: DISLVGGG)

• Disease Name: Salivary gland carcinoma
• Synonyms: salivary carcinoma; salivary gland cancer; salivary gland carcinoma; saliva-secreting gland carcinoma; carcinoma of the salivary gland; carcinoma of salivary gland; carcinoma of saliva-secreting gland
• Definition: A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
• Disease Hierarchy:
  :
  DISH9F1N: Carcinoma
  DISZXMVL: Oral cavity carcinoma
  DISLVGGG: Salivary gland carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0000521
  UMLS CUI: C0948750
  MedGen ID: 215302

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACACB	TTY84UG	Strong	Biomarker	[1]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GAGE7	OTF8BTR9	moderate	Biomarker	[2]
RAD52	OT0OTDHI	Strong	Genetic Variation	[3]
TSC22D1	OTN4GFWD	Definitive	Biomarker	[4]

References

• [1] Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells.BMC Cancer. 2013 Mar 22;13:141. doi: 10.1186/1471-2407-13-141.
• [2] Expression of cancer/testis antigens in salivary gland carcinomas with reference to MAGE-A and NY-ESO-1 expression in adenoid cystic carcinoma.Histopathology. 2017 Aug;71(2):305-315. doi: 10.1111/his.13226. Epub 2017 Jun 2.
• [3] Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control study.PLoS One. 2015 Jun 2;10(6):e0128753. doi: 10.1371/journal.pone.0128753. eCollection 2015.
• [4] TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer.Curr Cancer Drug Targets. 2004 Sep;4(6):521-9. doi: 10.2174/1568009043332844.