Details of Disease

General Information of Disease (ID: DISM7JPJ)

Disease Name Dermatophytosis
Synonyms ringworm; dermatomycosis; skin diseases, fungal; skin disease, fungal; fungal skin diseases; fungal skin disease
Disease Class 1F28: Dermatophytosis
Definition
A common fungal infection of the stratum corneum of the skin, hair, or nails by a dermatophyte. It is characterized by itching, inflammation, redness of the skin, small papular vesicles, central clearing, fissures, scaling, and/or hair loss in the affected area.|Editor note: check cutaneous vs superficial
Disease Hierarchy
DISCS7GV: Superficial mycosis
DISXMEII: Tinea infection
DISM7JPJ: Dermatophytosis
ICD Code
ICD-11
ICD-11: 1F28.2
ICD-10
ICD-10: B35.3
Disease Identifiers
MONDO ID
MONDO_0004678
UMLS CUI
C0011636
MedGen ID
3768
SNOMED CT ID
47382004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Haloprogin DMH4IVU Approved Small molecular drug [1]
Tolnaftate DM28MU7 Approved Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CLEC6A TTQ02HK Definitive Biomarker [3]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CARD9 OTJ81AWD Limited Genetic Variation [4]
DEFB104A OTLQZR6K Definitive Altered Expression [5]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Drug information of Tolnaftate, 2008. eduDrugs.
3 Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.Innate Immun. 2016 Jul;22(5):316-24. doi: 10.1177/1753425916645392. Epub 2016 Apr 26.
4 Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda).J Cutan Pathol. 2020 Feb;47(2):166-170. doi: 10.1111/cup.13574. Epub 2019 Oct 29.
5 Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis.J Invest Dermatol. 2015 Mar;135(3):750-758. doi: 10.1038/jid.2014.369. Epub 2014 Sep 1.