Details of Disease

General Information of Disease (ID: DISNEQBZ)

Disease Name Disorder of calcium metabolism
Synonyms calcium metabolism disease; calcium metabolism disorder; disorder of calcium metabolism
Disease Class 5C64: Mineral absorption/transport disorder
Definition
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.|Defined in terms of GO calcium ion homeostatis. Also consistent with HPO. Note advice from GO as calcium ions are neither created or destroyed is not metabolic process in terms of go, but name retained for purposes of consistency with e.g. Snomed and Mesh, Consider relocating this as a sibling of metabolic disease.
Disease Hierarchy
DIS71G5H: Metabolic disorder
DISV96AT: Mineral metabolism disease
DISNEQBZ: Disorder of calcium metabolism
ICD Code
ICD-11
ICD-11: 5C64.5
ICD-10
ICD-10: E83.5
Expand ICD-11
'5C64.5
Expand ICD-10
'E83.5
Disease Identifiers
MONDO ID
MONDO_0005557
MESH ID
D002128
UMLS CUI
C0006705
MedGen ID
714
SNOMED CT ID
71638002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Elcatonin DM5QZ5E Approved Small molecular drug [1]
Maxacalcitol DMGT0KV Approved Small molecular drug [2]
Secalciferol DMZ1ZQG Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CYP24A1 TT82UI1 Limited CausalMutation [3]
CASR TTBUYHA Strong Genetic Variation [4]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2784).
3 CYP24A1 mutations in idiopathic infantile hypercalcemia.N Engl J Med. 2011 Nov 3;365(18):1741; author reply 1742-3. doi: 10.1056/NEJMc1110226.
4 Roles of the calcium sensing receptor in digestive physiology and pathophysiology (review).Int J Oncol. 2014 Oct;45(4):1355-62. doi: 10.3892/ijo.2014.2560. Epub 2014 Jul 25.