General Information of Disease (ID: DIS71G5H)

Disease Name Metabolic disorder
Synonyms disease of metabolism; metabolic process disease; metabolic disease; disorder of metabolic process; metabolic disorder
Disease Class 5C50-5D2Z: Metabolic disorder
Definition A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.
Disease Hierarchy
DISH7H5I: Human disease
DIS71G5H: Metabolic disorder
ICD Code
ICD-11
ICD-11: 5C50-5D2Z
Disease Identifiers
MONDO ID
MONDO_0005066
MESH ID
D008659
UMLS CUI
C0025517
MedGen ID
44376
SNOMED CT ID
30390004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Eliglustat tartrate DMSRZAO Approved Small molecular drug [1]
Taliglucerase alfa DM3PZXN Approved NA [2]
Velaglucerase alfa DM4BOAS Approved NA [3]
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This Disease is Treated as An Indication in 12 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
SYR-472 DM9L1AC Phase 3 Small molecular drug [4]
INS-1 DMKRGVJ Phase 2 NA [6]
Isofagomine tartrate DM2RS0V Phase 2 Small molecular drug [7]
MGTA-456 DMT6IYM Phase 2 Cell therapy [8]
MPSK3169A DMMRYEK Phase 2 NA [9]
RG-4929 DMT4QRD Phase 2 Small molecular drug [10]
AP-1030 DMBGA35 Phase 1/2 NA [11]
KD-101 DMSWFGS Phase 1 NA [12]
KD3010 DMNFDYE Phase 1 NA [13]
P1201-07 DMXBYJF Phase 1 NA [14]
TM38837 DMCFGD4 Phase 1 Small molecular drug [15]
XL652/XL014 DM89NML Phase 1 NA [16]
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⏷ Show the Full List of 12 Drug(s)
This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial
Drug Name Drug ID Highest Status Drug Type REF
Heparin DM4ZP3W Phase 2/3 Trial Small molecular drug [5]
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This Disease is Treated as An Indication in 3 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivative 1 DMB1JG2 Patented Small molecular drug [17]
PMID26936077-Compound-13 DMXK6LV Patented Small molecular drug [18]
PMID26936077-Compound-34 DMIZL8D Patented Small molecular drug [18]
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This Disease is Treated as An Indication in 4 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AMG-221 DMFCKJ1 Discontinued in Phase 1 Small molecular drug [19]
PS522501 DM5ZCSM Discontinued in Phase 1 NA [20]
BVT-3498 DMOZQHX Terminated NA [24]
CS-204 DM1E7H3 Terminated NA [25]
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This Disease is Treated as An Indication in 3 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
HPP-851 DM69UZG Preclinical NA [21]
MC-3002 DM7UGY9 Preclinical NA [22]
TZP-301 DME8AL0 Preclinical NA [23]
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This Disease is Treated as An Indication in 19 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
A-849531 DMJBPR3 Investigative NA [26]
ACE-06X DMZJ4XA Investigative NA [27]
ARX-618 DM8NBJI Investigative NA [27]
AZP-03 DMSR31G Investigative NA [27]
BIM-64152 DMFO2E8 Investigative NA [27]
Debio-0930 DMFTNAP Investigative NA [28]
EX-1311 DMBKM30 Investigative NA [29]
FGF21-PKE Adnectin DMSPX64 Investigative NA [27]
INT-777 DMTPB8A Investigative Small molecular drug [30]
LPMD DMWI5GB Investigative NA [27]
MGN-5804 DMVCKZH Investigative NA [27]
NNZ-3006 DM835LX Investigative NA [27]
PEGylated PYY-3-36 DM6K3G7 Investigative NA [31]
PF-04094667 DMDL2JF Investigative NA [27]
SBC-105 DM632RG Investigative NA [27]
SIL-187 DMU2CEE Investigative NA [27]
SUVN-G1031 DMVDHBT Investigative NA [32]
ThermoStem DMIIZYL Investigative NA [27]
UMN-03 DMZP8W0 Investigative NA [27]
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⏷ Show the Full List of 19 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 240 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADRB3 TTMXGCW Limited Biomarker [33]
CYP2B6 TTMH124 Limited Biomarker [34]
ESRRA TTPNQAC Limited Biomarker [35]
HTR2A TTJQOD7 Limited Biomarker [36]
PGC TT7K6AD Limited Biomarker [37]
PRDX5 TTLPJWH Limited Biomarker [38]
SLC13A5 TTFIMH7 Limited Biomarker [39]
SNAP25 TTYQWA0 Limited Biomarker [40]
OTC TT5KIO9 Disputed Biomarker [41]
UCP3 TT12RJK Disputed Biomarker [42]
ARRB2 TT8SO2I moderate Biomarker [33]
IFNL1 TTM624L moderate Biomarker [43]
OLR1 TTKSND3 moderate Biomarker [44]
SELPLG TTS5K8U moderate Biomarker [45]
SLC22A2 TT0XOJN moderate Biomarker [46]
ABCA1 TTJW1GN Strong Biomarker [47]
ABHD6 TTSINOV Strong Biomarker [48]
ACAT1 TTK3C21 Strong Biomarker [49]
ACLY TT0Z6Y2 Strong Biomarker [50]
ADAMTS5 TTXSU2Y Strong Biomarker [51]
ADCYAP1R1 TT5OREU Strong Biomarker [52]
ADK TTL732K Strong Biomarker [53]
ADRA1A TTNGILX Strong Biomarker [54]
ADRA2A TTWG9A4 Strong Genetic Variation [55]
ADRA2B TTWM4TY Strong Biomarker [54]
AGTR1 TT8DBY3 Strong Biomarker [56]
AGXT TTF5NVW Strong Altered Expression [57]
AHR TT037IE Strong Biomarker [58]
AHSG TTKF4WV Strong Biomarker [59]
ALPL TTMR5UV Strong Genetic Variation [60]
ANGPTL4 TTWALY5 Strong Biomarker [61]
APLN TT87D3J Strong Biomarker [62]
APLNR TTJ8E43 Strong Biomarker [62]
AQP9 TTQEI32 Strong Biomarker [63]
AZGP1 TTUPYLV Strong Biomarker [64]
BMPR2 TTGKF90 Strong Genetic Variation [65]
BRS3 TTKYEPM Strong Biomarker [54]
CA5A TT75WPO Strong Altered Expression [66]
CASR TTBUYHA Strong Biomarker [67]
CHRNA2 TTF4E0J Strong Altered Expression [68]
CLCN2 TT30NW6 Strong Biomarker [69]
CNTF TTGEM5Q Strong Biomarker [70]
CPS1 TT42M75 Strong Genetic Variation [71]
CRBN TTDKGTC Strong Biomarker [72]
CRTC2 TTFWETR Strong Biomarker [73]
CRY1 TT5MLZR Strong Genetic Variation [74]
CXCR6 TT2BVUA Strong Biomarker [54]
CYP11B1 TTIQUX7 Strong Altered Expression [75]
CYP11B2 TT9MNE2 Strong Genetic Variation [76]
DGAT1 TT0GV3R Strong Biomarker [77]
DGAT2 TTRHEQ4 Strong Biomarker [78]
DPP4 TTDIGC1 Strong Altered Expression [79]
EDNRA TTKRD0G Strong Biomarker [54]
EHMT1 TTOFXD7 Strong Biomarker [80]
EIF2AK4 TT9U4EP Strong Biomarker [81]
EPAS1 TTWPA54 Strong Biomarker [82]
ERN1 TTKIAT3 Strong Biomarker [83]
ESRRB TTKF0XS Strong Biomarker [84]
ESRRG TT9ZRHB Strong Biomarker [85]
F7 TTF0EGX Strong Biomarker [86]
FABP2 TTS4YLO Strong Genetic Variation [87]
FABP4 TTHWMFZ Strong Biomarker [88]
FFAR2 TT0FYAN Strong Biomarker [89]
FGF10 TTNPEFX Strong Biomarker [90]
FGF19 TTGCH11 Strong Biomarker [91]
FGF21 TTQ916P Strong Biomarker [92]
FGF23 TT2IZ4K Strong Genetic Variation [93]
FKBP4 TTHY0FT Strong Biomarker [94]
FKBP5 TT0J5KQ Strong Biomarker [94]
FSHR TTZFDBT Strong Biomarker [95]
FTO TTFW3BT Strong Biomarker [96]
G6PC TTBQMJ8 Strong Biomarker [97]
GAA TTLPC70 Strong Genetic Variation [98]
GCG TT6Y4PN Strong Biomarker [99]
GCGR TT9O6WS Strong Biomarker [100]
GCH1 TTLSWP6 Strong Biomarker [101]
GCK TTDLNGZ Strong Biomarker [102]
GDF15 TT4MXVG Strong Biomarker [103]
GHSR TTWDC17 Strong Biomarker [104]
GIPR TTYMKBE Strong Biomarker [105]
GLA TTIS03D Strong Genetic Variation [106]
GLP1R TTVIMDE Strong Biomarker [105]
GLP2R TT1YWO5 Strong Biomarker [107]
GPBAR1 TTSDVTR Strong Biomarker [108]
GPR119 TT7QNVC Strong Biomarker [109]
GPR139 TTOL9B0 Strong Biomarker [110]
GPR18 TTSLJAR Strong Biomarker [111]
GPR35 TT254XD Strong Altered Expression [112]
GPR84 TTG0MQD Strong Biomarker [113]
GPRC6A TTI1PRE Strong Biomarker [54]
GRK2 TTAZ3MN Strong Biomarker [114]
GRM4 TTICZ1O Strong Biomarker [115]
GSK3A TTQWAU1 Strong Biomarker [116]
HDAC11 TT8K17W Strong Altered Expression [117]
HMBS TTT0HW3 Strong Genetic Variation [118]
HNF4A TT2F3CD Strong Biomarker [119]
HOXA5 TTXSVQP Strong Biomarker [120]
HSD11B1 TTN7BL9 Strong Biomarker [121]
HSD11B2 TT9H85R Strong Altered Expression [122]
HSP90AB1 TTH5YN2 Strong Biomarker [123]
HSPA8 TTMQL3K Strong Altered Expression [124]
IAPP TTHN8EM Strong Biomarker [125]
IDE TT2EDHU Strong Biomarker [126]
IDUA TT0IUKX Strong Genetic Variation [127]
INHBA TTVB30D Strong Biomarker [128]
INS TTZOPHG Strong Biomarker [129]
IRF3 TTYR7OH Strong Biomarker [130]
IRS1 TTAJSQ0 Strong Genetic Variation [131]
KDM3A TTKXS4A Strong Biomarker [132]
KDM4A TTZHPB8 Strong Biomarker [133]
KDM7A TT0NYMP Strong Biomarker [134]
KHK TTPAFR9 Strong Biomarker [135]
KLB TTARBVH Strong Altered Expression [136]
KLK7 TTE6GTB Strong Biomarker [137]
LBP TTVQJLY Strong Altered Expression [138]
LCN2 TTKTLAI Strong Biomarker [139]
LDLR TTH0DUS Strong Biomarker [140]
LEP TTBJEZ5 Strong Genetic Variation [141]
LEPR TT0HD6V Strong Biomarker [142]
LILRB4 TTREOKA Strong Altered Expression [143]
LIPE TTLUQ8E Strong Biomarker [144]
LPAR2 TTB7Y8I Strong Biomarker [54]
LPAR3 TTE2YJR Strong Biomarker [54]
MAPKAPK5 TT3UJ7Z Strong Altered Expression [145]
MBOAT4 TTSYOWR Strong Biomarker [146]
MC3R TTNI91K Strong Biomarker [147]
MC4R TTD0CIQ Strong Biomarker [119]
METAP2 TTZL0OI Strong Biomarker [148]
MGAM TTXWASR Strong Biomarker [149]
MGAT1 TTYJRN5 Strong Biomarker [150]
MGAT2 TTJOW1I Strong Biomarker [151]
MKNK1 TTEZAUX Strong Biomarker [152]
MKNK2 TTRECN3 Strong Biomarker [152]
MOGAT2 TTN17BP Strong Biomarker [153]
MRGPRX1 TTIX6PK Strong Biomarker [54]
MSTN TTM8I2X Strong Biomarker [154]
MTNR1A TT0WAIE Strong Genetic Variation [155]
MTNR1B TT32JK8 Strong Genetic Variation [155]
MVK TT5DFHW Strong Biomarker [156]
NLRP3 TT4EN8X Strong Biomarker [157]
NLRX1 TTKT026 Strong Biomarker [158]
NME1 TTDY8JH Strong Genetic Variation [159]
NOD1 TTYSRXM Strong Biomarker [160]
NPC1L1 TTPD1CN Strong Biomarker [161]
NPR3 TTWVLS6 Strong Biomarker [162]
NPY TT64REZ Strong Biomarker [163]
NPY2R TTJ6WK9 Strong Genetic Variation [164]
NR0B2 TT25A9Q Strong Biomarker [165]
NR1H3 TTECBXN Strong Altered Expression [166]
NR1H4 TTS4UGC Strong Biomarker [167]
NR1I3 TTRANFM Strong Biomarker [168]
NR4A1 TTMXE2Q Strong Biomarker [169]
NRG4 TTWAGKJ Strong Altered Expression [170]
OSM TTIVXSE Strong Biomarker [171]
OXER1 TT7WBSV Strong Biomarker [54]
PAH TTGSVH2 Strong Biomarker [172]
PARP2 TTQ4V96 Strong Biomarker [173]
PCCA TT1JDE3 Strong Genetic Variation [174]
PCCB TT5LURU Strong Genetic Variation [174]
PCSK9 TTNIZ2B Strong Biomarker [175]
PDE3B TTN34SQ Strong Biomarker [176]
PDE5A TTJ0IQB Strong Biomarker [177]
PDX1 TT8SGZK Strong Biomarker [178]
PNP TTMCF1Y Strong Genetic Variation [179]
PON1 TT9LX82 Strong Biomarker [180]
PPARA TTJ584C Strong Biomarker [181]
PPARD TT2JWF6 Strong Biomarker [182]
PPARG TTT2SVW Strong Biomarker [183]
PRCP TTTJZ4M Strong Biomarker [184]
PTH1R TTFPD47 Strong Biomarker [185]
PTPN1 TTELIN2 Strong Biomarker [186]
PYGM TTZHY6R Strong Biomarker [187]
REN TTB2MXP Strong Biomarker [188]
RIPK2 TTCQ2E5 Strong Biomarker [160]
RXRG TTH029C Strong Biomarker [189]
SCAP TTL6U2P Strong Altered Expression [190]
SCD TT6RIOV Strong Biomarker [191]
SERPINA1 TTA7UJC Strong Biomarker [192]
SIRT5 TTH0IOD Strong Biomarker [193]
SIRT6 TTUXYWF Strong Biomarker [194]
SLC22A12 TTA592U Strong Genetic Variation [195]
SLC22A8 TTTQR47 Strong Biomarker [196]
SLC25A4 TTU5A6Q Strong Biomarker [197]
SLC2A4 TTP6MT5 Strong Altered Expression [198]
SLC2A9 TTIF3GB Strong Biomarker [199]
SLC36A1 TTUYIZW Strong Biomarker [200]
SLC37A4 TT1KPBZ Strong Genetic Variation [201]
SLC5A1 TT2UE56 Strong Biomarker [202]
SLC5A2 TTF8JAT Strong Biomarker [203]
SLC6A9 TTHJTF7 Strong Biomarker [150]
SMPD1 TTJTM88 Strong Biomarker [204]
SORD TTLSRBZ Strong Biomarker [205]
SORT1 TTRX9AV Strong Biomarker [206]
SREBF1 TTER0UB Strong Altered Expression [207]
SREBF2 TTRQ4AP Strong Biomarker [208]
SRPK2 TTCZEJ9 Strong Biomarker [209]
SSTR4 TTAE1BR Strong Biomarker [54]
STAB1 TTJFEOC Strong Biomarker [210]
STC2 TT4EFTR Strong Biomarker [211]
STOML2 TTOI329 Strong Biomarker [212]
TAAR1 TTIU98M Strong Genetic Variation [213]
TIPARP TT2FRAN Strong Biomarker [173]
TM6SF2 TTE1OHM Strong Biomarker [214]
TPH1 TTZSJHV Strong Biomarker [215]
TRPA1 TTELV3W Strong Altered Expression [216]
TYMP TTO0IB8 Strong Genetic Variation [217]
UCP1 TTI12YJ Strong Biomarker [218]
UCP2 TTSC2YM Strong Biomarker [219]
XDH TT7RJY8 Strong Altered Expression [220]
AGRP TT4DE1O Definitive Biomarker [221]
ANGPTL3 TT59GO7 Definitive Biomarker [222]
AOC3 TT7HC21 Definitive Biomarker [223]
APOC3 TTXOZQ1 Definitive Genetic Variation [224]
CASP4 TT6KIOT Definitive Biomarker [225]
CD36 TTPJMCU Definitive Biomarker [226]
CETP TTFQAYR Definitive Altered Expression [227]
CPE TTXPWO6 Definitive Biomarker [221]
CTNS TT1W2ZS Definitive Genetic Variation [228]
CUBN TT9YLCR Definitive Genetic Variation [229]
CYP21A2 TTP4GLG Definitive Genetic Variation [230]
DDIT4 TTVEOY6 Definitive Biomarker [231]
DNM2 TTVRA5G Definitive Biomarker [232]
ENPP2 TTSCIM2 Definitive Biomarker [233]
FFAR4 TT08JVB Definitive Biomarker [234]
GAD2 TT7UY6K Definitive Biomarker [235]
GALC TT5IZRB Definitive Altered Expression [236]
GALE TTGRHIB Definitive Genetic Variation [237]
GALNS TTT9YPO Definitive Genetic Variation [238]
GIP TT40HS5 Definitive Biomarker [239]
GPR55 TTNET8J Definitive Biomarker [240]
IL31RA TT9HPX0 Definitive Genetic Variation [241]
INSR TTCBFJO Definitive Genetic Variation [242]
LCAT TTGZ91P Definitive Biomarker [243]
LPL TTOF3WZ Definitive Genetic Variation [244]
MAPK10 TT056SO Definitive Biomarker [245]
PPARGC1B TTKSQ3W Definitive Biomarker [246]
SCN8A TT54ERL Definitive Biomarker [247]
SLC44A4 TT0NYDG Definitive Biomarker [248]
TPH2 TT3KLDP Definitive Genetic Variation [249]
UMPS TTAFJUD Definitive Biomarker [250]
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⏷ Show the Full List of 240 DTT(s)
This Disease Is Related to 14 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ATP7A DT0LT17 Strong Genetic Variation [152]
SLC13A1 DTIZEMV Strong Biomarker [251]
SLC16A11 DTYT1WO Strong Biomarker [252]
SLC22A5 DT3HUVD Strong Altered Expression [46]
SLC25A13 DTDSYAQ Strong Genetic Variation [253]
SLC25A19 DTT82QK Strong Biomarker [254]
SLC26A2 DTFSLX5 Strong Biomarker [251]
SLC2A5 DTOR02F Strong Altered Expression [255]
SLC37A1 DTH9SQJ Strong Biomarker [256]
ABCB5 DTKVEXO Definitive Biomarker [222]
ABCD1 DTKM9DZ Definitive Genetic Variation [257]
SLC27A1 DTKDTML Definitive Genetic Variation [258]
SLC2A2 DTUJPOL Definitive Biomarker [259]
SLC34A3 DTKS517 Definitive Genetic Variation [260]
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⏷ Show the Full List of 14 DTP(s)
This Disease Is Related to 23 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP7B1 DE36TMY Limited Genetic Variation [261]
PMM2 DEBRX3L Disputed Genetic Variation [262]
AKR1D1 DEVON3M Strong Biomarker [263]
APRT DE2MV1R Strong Genetic Variation [264]
CYP2C18 DEZMWRE Strong Altered Expression [265]
CYP8B1 DETL4WB Strong Biomarker [266]
DHCR7 DEL7GFA Strong Genetic Variation [267]
FXN DEXVHDB Strong Genetic Variation [268]
GALK1 DE3OP9S Strong Biomarker [269]
GLDC DEIN8FB Strong Biomarker [150]
GPT DER5HFI Strong Biomarker [270]
HSD17B10 DEGSPC9 Strong Biomarker [271]
NMNAT3 DERBKPU Strong Biomarker [272]
NNMT DECVGJ3 Strong Biomarker [273]
PGM1 DEA3VM1 Strong Biomarker [274]
SI DE5EO4Y Strong Biomarker [149]
AOC2 DE8DP90 Definitive Biomarker [223]
CYP7A1 DEDZRQ1 Definitive Biomarker [275]
FAAH DEUM1EX Definitive Genetic Variation [276]
IPMK DESA9EX Definitive Biomarker [277]
MAT1A DEQ6NC9 Definitive Biomarker [278]
WARS1 DEPVE0M Definitive Biomarker [279]
WARS2 DEPTKBQ Definitive Biomarker [279]
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⏷ Show the Full List of 23 DME(s)
This Disease Is Related to 258 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACACA OT5CQPZY Limited Biomarker [280]
ADIPOR1 OT65ZFZN Limited Genetic Variation [281]
APOM OTI3FQQC Limited Biomarker [282]
CH25H OT9S2BSW Limited Genetic Variation [261]
CRABP1 OTISDG5X Limited Biomarker [283]
DHTKD1 OTDQLSNT Limited Genetic Variation [284]
AQP2 OTQLBKK6 Disputed Biomarker [285]
BFAR OTTBG0V7 Disputed Genetic Variation [286]
C2 OTHMF4YM Disputed Genetic Variation [287]
GALNT8 OT05BKVP Disputed Biomarker [288]
AAAS OTJT9T23 moderate Biomarker [289]
BIK OTTH1T3D moderate Biomarker [290]
FNDC5 OT5CSK9X moderate Biomarker [291]
GPIHBP1 OTDF8R2M moderate Altered Expression [292]
ID3 OTUULW5Z moderate Biomarker [293]
ACADM OTA4P0FC Strong Biomarker [294]
ACOX1 OTM0A0DY Strong Biomarker [295]
ACSF3 OT3WZW8S Strong Genetic Variation [296]
ADAMTS18 OTRMFI04 Strong Biomarker [297]
AFM OTPOR8IO Strong Biomarker [298]
AGL OTWBM7WY Strong Genetic Variation [299]
AGTRAP OT02N7LD Strong Altered Expression [56]
ALOXE3 OT76J52A Strong Biomarker [300]
AMFR OTQRX7LC Strong Biomarker [301]
AMT OTQYEWZQ Strong Biomarker [150]
APCDD1 OTV9AD0L Strong Altered Expression [302]
APOA5 OTEVKLVA Strong Biomarker [303]
ARC OTN2QQPG Strong Biomarker [304]
ARHGEF19 OTKD9XY9 Strong Altered Expression [305]
ARID5A OTQT7CG9 Strong Biomarker [306]
ARR3 OTRZ00CH Strong Biomarker [67]
ASS1 OT4ZMG0Q Strong Biomarker [307]
ATP5F1D OTXTAG2V Strong Genetic Variation [308]
BCO2 OTP1L0BZ Strong Biomarker [309]
BGLAP OTK1YLWQ Strong Biomarker [310]
BTD OTJYTQ69 Strong Genetic Variation [311]
C1QTNF5 OTLKU5I2 Strong Biomarker [312]
CARD9 OTJ81AWD Strong Biomarker [313]
CAVIN3 OTOLBK79 Strong Genetic Variation [74]
CCDC80 OTOZSYEM Strong Biomarker [314]
CCDC88A OT3SSYYC Strong Biomarker [128]
CCL27 OTUZYC61 Strong Biomarker [315]
CCL28 OTY6XNQ7 Strong Biomarker [316]
CCN5 OTADU8JJ Strong Biomarker [317]
CD180 OTITK5E6 Strong Biomarker [318]
CDKAL1 OTA0SGNE Strong Biomarker [319]
CERS6 OTOP4GV1 Strong Biomarker [320]
CHGA OTXYX5JH Strong Genetic Variation [321]
CHPT1 OT4FJ0K3 Strong Biomarker [322]
CLOCK OTNEOJY7 Strong Genetic Variation [323]
CNBP OTTGM9NK Strong Biomarker [324]
COQ9 OTM2T1FI Strong Biomarker [325]
CPT1A OTI862QH Strong Biomarker [322]
CPT2 OTIN6G20 Strong Biomarker [326]
CREB3 OT9617UO Strong Altered Expression [327]
CREG1 OTRHJ8HK Strong Biomarker [328]
CXADR OT9ZP02A Strong Biomarker [67]
CXCL16 OTD49T9R Strong Biomarker [329]
D2HGDH OTLHXW69 Strong Genetic Variation [330]
DMP1 OTBWBWW7 Strong Biomarker [331]
DSC3 OTYG47F8 Strong Biomarker [332]
DSG1 OT11HC3A Strong Biomarker [333]
DST OTHZBM4X Strong Biomarker [334]
DUOX1 OTQ2AEW0 Strong Biomarker [335]
DUOX2 OTU14HCN Strong Biomarker [335]
DUSP2 OTH54FMR Strong Biomarker [52]
ECHS1 OTS0593S Strong Genetic Variation [336]
ELOVL6 OTB26UJJ Strong Biomarker [337]
EMD OTR8ZANE Strong Biomarker [338]
ENO3 OT3HYKYI Strong Biomarker [187]
ETFDH OTOSKSFH Strong Genetic Variation [339]
ETHE1 OTP9A2BQ Strong Biomarker [340]
FAH OTGZA1YR Strong Genetic Variation [341]
FAM3B OTC2S91N Strong Biomarker [342]
FAM3D OTM3GWFP Strong Biomarker [343]
FANCC OTTIDM3P Strong Biomarker [344]
FDCSP OT8KGE9M Strong Biomarker [345]
FETUB OT7V07NI Strong Biomarker [346]
FGA OTMIHY80 Strong Biomarker [347]
FLAD1 OTY8R02L Strong Genetic Variation [348]
FZD4 OTGLZIE0 Strong Biomarker [54]
GALNT3 OT7M67WT Strong Genetic Variation [349]
GALT OTCATU66 Strong Biomarker [350]
GBE1 OTK2N05B Strong Biomarker [187]
GCKR OTSIWXGG Strong Biomarker [351]
GDF11 OTOSNMND Strong Biomarker [352]
GMFG OTMPNSE7 Strong Biomarker [353]
GNA13 OTVDL515 Strong Biomarker [354]
GNPTAB OT2Z03OB Strong Genetic Variation [355]
GPR151 OT7EACU6 Strong Biomarker [54]
GPR42 OTEB0ROY Strong Biomarker [54]
GYG1 OT9PU6I2 Strong Biomarker [187]
GYPA OTABU4YV Strong Biomarker [356]
GYS2 OTCKIUYR Strong Genetic Variation [357]
HCFC1 OT0UCK62 Strong Biomarker [358]
HPX OT14T7Q1 Strong Biomarker [359]
IGFBP4 OT2HZRBD Strong Biomarker [360]
IKBKE OT5VYOSM Strong Biomarker [361]
INPPL1 OTCDAVBQ Strong Biomarker [362]
IRF2BP2 OTSSRRCA Strong Altered Expression [363]
IRF6 OTKJ44EV Strong Biomarker [364]
KAT5 OTL7257A Strong Biomarker [365]
KL OTD4VWU6 Strong Genetic Variation [93]
KLF11 OTKVQDJD Strong Genetic Variation [366]
KLF15 OTGMQMVR Strong Biomarker [367]
KLF7 OTS3YVA0 Strong Biomarker [368]
L2HGDH OTW6C712 Strong Genetic Variation [369]
LAMTOR5 OTER0U8L Strong Biomarker [370]
LEAP2 OTUOPIS5 Strong Biomarker [371]
LGR6 OTPZ1PWR Strong Biomarker [54]
LIAS OTOSW67J Strong Altered Expression [372]
LITAF OTT5JX1F Strong Altered Expression [373]
LNPK OTOBNX6G Strong Biomarker [374]
LPIN2 OTRRTMXX Strong Biomarker [375]
LRPAP1 OT6DVD2Q Strong Biomarker [376]
MAF1 OTKB0N8Q Strong Biomarker [377]
MAP2K3 OTI2OREX Strong Altered Expression [145]
MDH1 OTJEO4E8 Strong Biomarker [378]
METTL3 OTSXP1M3 Strong Biomarker [379]
MFAP1 OTZN4FT3 Strong Genetic Variation [264]
MFAP2 OTMHVBTV Strong Biomarker [380]
MFAP5 OT46VXSG Strong Genetic Variation [381]
MFRP OTHY9ZA5 Strong Biomarker [312]
MGP OTZWU3FU Strong Altered Expression [382]
MLXIPL OTR9MLLW Strong Biomarker [383]
MMD OTB5I4OC Strong Biomarker [384]
MRGPRX3 OTRKCCDS Strong Biomarker [54]
MRGPRX4 OTOBHZVA Strong Biomarker [54]
MYLIP OTL0PFGV Strong Biomarker [385]
NCOR1 OT04XNOU Strong Biomarker [386]
NCOR2 OTY917X0 Strong Biomarker [387]
NIF3L1 OT4MP90J Strong Biomarker [101]
NOX1 OTZPJQCC Strong Biomarker [388]
NPHS2 OTLCNUII Strong Altered Expression [389]
NR2C2 OTDZWVOJ Strong Biomarker [390]
NRIP1 OTIZOJQV Strong Biomarker [391]
NUCB2 OTHO6JWN Strong Altered Expression [392]
NUMA1 OTTKAVG4 Strong Altered Expression [393]
NUSAP1 OT85HIJ5 Strong Biomarker [374]
PA2G4 OT7IG7HT Strong Biomarker [394]
PCK2 OTJ8LX4N Strong Biomarker [395]
PDHX OTG7O271 Strong Biomarker [178]
PDK4 OTCMHMBZ Strong Biomarker [396]
PEA15 OTKCKTSX Strong Biomarker [247]
PGAM2 OT9BE03I Strong Biomarker [187]
PGP OT6QQ7OR Strong Biomarker [256]
PKNOX1 OTUDMNHX Strong Biomarker [397]
PLXND1 OTNK9ALK Strong Biomarker [398]
PNPLA2 OTR3ERMR Strong Biomarker [399]
POLDIP3 OTTB5SV7 Strong Biomarker [400]
PRKAA1 OT7TNF0L Strong Biomarker [401]
PRKAA2 OTU1KZPV Strong Biomarker [401]
PRKAB1 OT1OG4QZ Strong Biomarker [401]
PRKD2 OTIFSVI8 Strong Altered Expression [402]
PRMT6 OT5V3XIN Strong Altered Expression [403]
PRPF6 OT3U0ABN Strong Biomarker [197]
PRPS1 OTN3A6CN Strong Genetic Variation [404]
PSMG1 OTZ5I6UM Strong Biomarker [52]
PTPRN2 OTL6SH28 Strong Posttranslational Modification [405]
PTS OTTYWQXR Strong Biomarker [406]
RALGAPB OTY8CGA3 Strong Biomarker [407]
RAMP3 OTX6XLLM Strong Biomarker [408]
RARRES2 OT1BJE8K Strong Biomarker [409]
RETN OTW5Z1NH Strong Biomarker [410]
RNF186 OTXNX8VL Strong Biomarker [411]
RPIA OT805SMH Strong Biomarker [412]
RRP8 OTGZHVVW Strong Biomarker [413]
RSAD2 OTCA9WCM Strong Altered Expression [414]
SARM1 OTEP4I5O Strong Biomarker [415]
SCO2 OTJQQDRS Strong Genetic Variation [217]
SELENOP OT02B8IR Strong Biomarker [416]
SEMA6A OTDQ7QAW Strong Biomarker [417]
SENP2 OTPQJXIR Strong Biomarker [418]
SERPINB1 OT5RDUFO Strong Biomarker [419]
SERPINF2 OTZGAF8B Strong Biomarker [420]
SHBG OTPWU5IW Strong Biomarker [421]
SIGLEC12 OTC36XP9 Strong Biomarker [422]
SIRT4 OT5S0J23 Strong Biomarker [423]
SLN OTERIU75 Strong Biomarker [424]
SMOC2 OTK1EQ49 Strong Biomarker [425]
SNTB2 OTIVMQ2S Strong Biomarker [426]
SPINK4 OTHTCW94 Strong Biomarker [164]
ST3GAL4 OTNENJZQ Strong Biomarker [427]
STEAP4 OTFTLAEZ Strong Biomarker [428]
STK25 OT4YPNTF Strong Biomarker [429]
STUB1 OTSUYI9A Strong Biomarker [430]
TAFA5 OT2SWBT6 Strong Biomarker [431]
TALDO1 OTDKV2S2 Strong Biomarker [432]
TM7SF2 OTILU5S7 Strong Biomarker [433]
TMEM102 OTXTYWXJ Strong Biomarker [434]
TMEM126B OT8JJ5TP Strong Biomarker [435]
TPI1 OT14KP4B Strong Biomarker [436]
TRDMT1 OTAYQ8ZF Strong Biomarker [437]
TRIB1 OTPEO17G Strong Biomarker [438]
TRIM13 OTQIUACB Strong Biomarker [67]
TRIM25 OT35SG1R Strong Biomarker [439]
TRIM69 OTTEGTRD Strong Biomarker [440]
TRIM72 OTFAFXPC Strong Altered Expression [441]
TRIM8 OTS6JFR0 Strong Biomarker [442]
TRPC4AP OTNJ9IFS Strong Biomarker [443]
ACVR1C OTOTYERF Definitive Altered Expression [444]
ACY1 OT9WU7X3 Definitive Biomarker [445]
ADCY3 OTGOQM6B Definitive Biomarker [446]
ADSL OTSNJALL Definitive Biomarker [447]
ALDH18A1 OT6W40XU Definitive Altered Expression [448]
ALKBH7 OTJVS8CF Definitive Biomarker [449]
AMPD1 OTU17BCI Definitive Genetic Variation [450]
AMPD2 OTBS30JU Definitive Genetic Variation [450]
ANGPTL8 OTQFINCD Definitive Altered Expression [451]
ANKH OTCN25R5 Definitive Genetic Variation [452]
APBB1 OTZPVSSC Definitive Biomarker [453]
ARID4B OTYLPILE Definitive Biomarker [454]
ARID5B OTUQ4CQY Definitive Biomarker [455]
AUH OT8VKBXX Definitive Genetic Variation [456]
CAPN10 OTS9LJW4 Definitive Biomarker [457]
CFC1 OT5DHGI8 Definitive Genetic Variation [458]
CIDEC OTMDZ56K Definitive Biomarker [459]
COL9A1 OTWBR27Y Definitive Biomarker [247]
COL9A2 OT1ZBDBV Definitive Biomarker [247]
COL9A3 OTCUJOEK Definitive Biomarker [247]
CRTC3 OTVIGVUW Definitive Genetic Variation [460]
CTNNA1 OTFC725Z Definitive Biomarker [461]
CTNNA3 OT9Z0P1E Definitive Biomarker [461]
DNAJC15 OTNDUKAA Definitive Altered Expression [462]
EIF6 OTEXMUED Definitive Biomarker [463]
G0S2 OT8FL49L Definitive Biomarker [464]
GCDH OTVQMZZN Definitive Genetic Variation [465]
GLUD1 OTXKOCUH Definitive Genetic Variation [466]
HADH OTJDOL20 Definitive Genetic Variation [466]
HADHA OTO557N2 Definitive Biomarker [467]
HBG1 OTVL4NSU Definitive Altered Expression [468]
HBG2 OT4J48JJ Definitive Altered Expression [468]
IARS1 OT9WXH5N Definitive Biomarker [469]
IVD OT8JFXUQ Definitive Genetic Variation [470]
KAT2A OTN0W2SW Definitive Altered Expression [471]
KLF14 OT8BXLBS Definitive Genetic Variation [472]
MACROD1 OTWFEVRW Definitive Biomarker [453]
MED13 OTP5LEJE Definitive Biomarker [473]
MGAT4A OT0ZW5FM Definitive Altered Expression [474]
NLRC3 OTWLLFFN Definitive Biomarker [475]
NPC2 OTE9UEJC Definitive Biomarker [476]
OCA2 OTDWIGBF Definitive Biomarker [247]
PBX1 OTORABGO Definitive Genetic Variation [477]
PLIN2 OTRXJ9UN Definitive Biomarker [478]
PPARGC1A OTHCDQ22 Definitive Biomarker [479]
PPL OTTM4WDO Definitive Genetic Variation [450]
PRM3 OT6574BF Definitive Biomarker [480]
REPIN1 OTVTPXNX Definitive Altered Expression [481]
SELENOS OTUEWIU9 Definitive Biomarker [482]
SH2D1A OTLU49I5 Definitive Biomarker [483]
SPAG8 OTZC5XP9 Definitive Altered Expression [484]
SPON2 OTE7JLNM Definitive Biomarker [485]
TAS2R9 OTB48LVU Definitive Biomarker [486]
TBPL2 OTDEC1KO Definitive Biomarker [487]
TFE3 OTM99ZWH Definitive Biomarker [488]
TNMD OTHLVA9G Definitive Altered Expression [489]
TPR OTUBBA4W Definitive Genetic Variation [490]
TRNT1 OTD57ILL Definitive Biomarker [491]
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⏷ Show the Full List of 258 DOT(s)

References

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89 Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8; 61(21):9534-9550.
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115 Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.Expert Opin Drug Discov. 2018 May;13(5):411-423. doi: 10.1080/17460441.2018.1443076. Epub 2018 Feb 28.
116 Emerging roles of GSK-3 in pathophysiology: Emphasis on cardio-metabolic disorders.Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118616. doi: 10.1016/j.bbamcr.2019.118616. Epub 2019 Nov 27.
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118 Self-efficacy and self-management strategies in acute intermittent porphyria.BMC Health Serv Res. 2019 Jul 3;19(1):444. doi: 10.1186/s12913-019-4285-9.
119 MC4R and HNF4 promoter methylation at birth contribute to triglyceride levels in childhood: A prospective cohort study.Medicine (Baltimore). 2019 Jul;98(28):e16424. doi: 10.1097/MD.0000000000016424.
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123 Inhibition of HSP90 Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.Theranostics. 2019 Aug 12;9(20):5769-5783. doi: 10.7150/thno.36505. eCollection 2019.
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126 Multiple functions of insulin-degrading enzyme: a metabolic crosslight?.Crit Rev Biochem Mol Biol. 2017 Oct;52(5):554-582. doi: 10.1080/10409238.2017.1337707. Epub 2017 Jun 21.
127 ZFN-Mediated InVivo Genome Editing Corrects Murine Hurler Syndrome.Mol Ther. 2019 Jan 2;27(1):178-187. doi: 10.1016/j.ymthe.2018.10.018. Epub 2018 Nov 1.
128 Circulating exosomes may identify biomarkers for cows at risk for metabolic dysfunction.Sci Rep. 2019 Sep 25;9(1):13879. doi: 10.1038/s41598-019-50244-7.
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130 Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease.Metabolism. 2018 Apr;81:13-24. doi: 10.1016/j.metabol.2017.09.010. Epub 2017 Oct 26.
131 Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries.Diabetes Care. 2013 Sep;36(9):2621-7. doi: 10.2337/dc12-2607. Epub 2013 Apr 17.
132 Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.Nat Commun. 2018 Apr 19;9(1):1566. doi: 10.1038/s41467-018-03868-8.
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135 Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). J Med Chem. 2017 Sep 28;60(18):7835-7849.
136 Overexpression of -Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity.Endocrinology. 2016 Apr;157(4):1467-80. doi: 10.1210/en.2015-1722. Epub 2016 Feb 22.
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138 Lipopolysaccharide-binding protein is a sensitive disease activity biomarker for rheumatoid arthritis.Clin Exp Rheumatol. 2018 Mar-Apr;36(2):233-240. Epub 2017 Aug 28.
139 Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications.Biochem Pharmacol. 2019 Nov;169:113626. doi: 10.1016/j.bcp.2019.113626. Epub 2019 Aug 30.
140 Salusin- attenuates hepatic steatosis and atherosclerosis in high fat diet-fed low density lipoprotein receptor deficient mice.Eur J Pharmacol. 2018 Jul 5;830:76-86. doi: 10.1016/j.ejphar.2018.04.026. Epub 2018 Apr 26.
141 The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.Aging Cell. 2019 Jun;18(3):e12874. doi: 10.1111/acel.12874. Epub 2019 Mar 1.
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144 Update on the synergistic effect of HSL and insulin in the treatment of metabolic disorders.Ther Adv Endocrinol Metab. 2019 Sep 20;10:2042018819877300. doi: 10.1177/2042018819877300. eCollection 2019.
145 Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice.J Cell Biochem. 2017 Aug;118(8):2395-2408. doi: 10.1002/jcb.25902. Epub 2017 Apr 25.
146 Ghrelin O-acyltransferase (GOAT) and energy metabolism.Sci China Life Sci. 2016 Mar;59(3):281-91. doi: 10.1007/s11427-015-4973-6. Epub 2016 Jan 6.
147 StructureActivity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH(2) at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands.Molecules. 2019 Apr 13;24(8):1463. doi: 10.3390/molecules24081463.
148 Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.J Pharmacol Exp Ther. 2018 May;365(2):301-313. doi: 10.1124/jpet.117.246272. Epub 2018 Feb 28.
149 Whole-exome sequencing reveals a novel mutation of MT-ND5 gene in a mitochondrial cardiomyopathy pedigree: Patients who show biventricular hypertrophy, hyperlactacidemia, pulmonary hypertension, and decreased exercise tolerance.Anatol J Cardiol. 2019 Jan;21(1):18-24. doi: 10.14744/AnatolJCardiol.2018.53258.
150 The effect of hyperglycinemic treatment in captive-bred Vervet monkeys (Chlorocebus aethiops).Metab Brain Dis. 2019 Oct;34(5):1467-1472. doi: 10.1007/s11011-019-00449-6. Epub 2019 Jun 22.
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152 Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold.Eur J Med Chem. 2019 Jan 15;162:735-751. doi: 10.1016/j.ejmech.2018.10.070. Epub 2018 Nov 2.
153 Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.FEBS Open Bio. 2020 Mar;10(3):316-326. doi: 10.1002/2211-5463.12778. Epub 2020 Feb 5.
154 Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise.J Clin Endocrinol Metab. 2018 Oct 1;103(10):3890-3899. doi: 10.1210/jc.2018-01056.
155 Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome.Mol Med Rep. 2019 Mar;19(3):2220-2230. doi: 10.3892/mmr.2019.9872. Epub 2019 Jan 17.
156 Respiratory deficiency in yeast mevalonate kinase deficient may explain MKD-associate metabolic disorder in humans.Curr Genet. 2018 Aug;64(4):871-881. doi: 10.1007/s00294-018-0803-2. Epub 2018 Jan 27.
157 Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders.J Cell Physiol. 2019 Sep;234(9):14773-14782. doi: 10.1002/jcp.28275. Epub 2019 Feb 11.
158 Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome.Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1883-1895. doi: 10.1016/j.bbadis.2018.03.003. Epub 2018 Mar 4.
159 Long-term outcome of expanded newborn screening at Boston children's hospital: benefits and challenges in defining true disease.J Inherit Metab Dis. 2017 Mar;40(2):209-218. doi: 10.1007/s10545-016-0004-4. Epub 2017 Jan 4.
160 Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia.Sci Rep. 2017 May 8;7(1):1578. doi: 10.1038/s41598-017-01822-0.
161 Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.Annu Rev Physiol. 2011;73:239-59. doi: 10.1146/annurev-physiol-012110-142233.
162 Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance.Sci Signal. 2017 Jul 25;10(489):eaam6870. doi: 10.1126/scisignal.aam6870.
163 A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans.Cell Physiol Biochem. 2018;45(1):88-107. doi: 10.1159/000486225. Epub 2017 Dec 22.
164 Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.Bioorg Med Chem Lett. 2017 Aug 15;27(16):3829-3832. doi: 10.1016/j.bmcl.2017.06.055. Epub 2017 Jun 23.
165 The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.Metabolism. 2019 Nov;100:153954. doi: 10.1016/j.metabol.2019.153954. Epub 2019 Aug 8.
166 Liver X receptor is targeted by microRNA-1 to inhibit cardiomyocyte apoptosis through a ROS-mediated mitochondrial pathway.Biochem Cell Biol. 2018 Feb;96(1):11-18. doi: 10.1139/bcb-2017-0154. Epub 2017 Oct 12.
167 Computational study of the binding mechanism between farnesoid X receptor and antagonist N-benzyl-N-(3-(tertbutyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) benzamide.J Biomol Struct Dyn. 2019 Apr;37(6):1628-1640. doi: 10.1080/07391102.2018.1462735. Epub 2018 May 2.
168 The Therapeutic Role of Xenobiotic Nuclear Receptors Against Metabolic Syndrome.Curr Drug Metab. 2019;20(1):15-22. doi: 10.2174/1389200219666180611083155.
169 Dual targeting of Nur77 and AMPK by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo.Int J Obes (Lond). 2019 May;43(5):952-962. doi: 10.1038/s41366-018-0276-x. Epub 2018 Dec 11.
170 Transplantation of neuregulin 4-overexpressing adipose-derived mesenchymal stem cells ameliorates insulin resistance by attenuating hepatic steatosis.Exp Biol Med (Maywood). 2019 May;244(7):565-578. doi: 10.1177/1535370219839643. Epub 2019 Apr 1.
171 Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains.Sci Rep. 2019 Sep 23;9(1):13706. doi: 10.1038/s41598-019-50110-6.
172 Effect of Delayed Diagnosis of Phenylketonuria With Imaging Findings of Bilateral Diffuse Symmetric White Matter Lesions: A Case Report and Literature Review.Front Neurol. 2019 Oct 4;10:1040. doi: 10.3389/fneur.2019.01040. eCollection 2019.
173 Metabolic roles of poly(ADP-ribose) polymerases.Semin Cell Dev Biol. 2017 Mar;63:135-143. doi: 10.1016/j.semcdb.2016.12.009. Epub 2016 Dec 21.
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175 Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.Metabolism. 2019 May;94:47-58. doi: 10.1016/j.metabol.2019.02.002. Epub 2019 Feb 12.
176 White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.Sci Rep. 2017 Jan 13;7:40445. doi: 10.1038/srep40445.
177 Ultrastructural Study of Clitoral Cavernous Tissue and Clitoral Blood Flow From Type 1 Diabetic Premenopausal Women on Phosphodiesterase-5 Inhibitor.J Sex Med. 2019 Mar;16(3):375-382. doi: 10.1016/j.jsxm.2019.01.003. Epub 2019 Feb 14.
178 Liraglutide protects -cell function by reversing histone modification of Pdx-1 proximal promoter in catch-up growth male rats.J Diabetes Complications. 2018 Nov;32(11):985-994. doi: 10.1016/j.jdiacomp.2018.08.002. Epub 2018 Aug 5.
179 Infusion of Sibling Marrow in a Patient with Purine Nucleoside Phosphorylase Deficiency Leads to Split Mixed Donor Chimerism and Normal Immunity.Front Pediatr. 2017 Jun 19;5:143. doi: 10.3389/fped.2017.00143. eCollection 2017.
180 Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol.J Lipid Res. 2019 Jan;60(1):168-175. doi: 10.1194/jlr.P088997. Epub 2018 Nov 19.
181 Multitarget PPAR agonists as innovative modulators of the metabolic syndrome.Eur J Med Chem. 2019 Jul 1;173:261-273. doi: 10.1016/j.ejmech.2019.04.030. Epub 2019 Apr 13.
182 Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome.Chem Pharm Bull (Tokyo). 2019;67(3):199-202. doi: 10.1248/cpb.c18-00627.
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184 Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects.PLoS One. 2018 May 17;13(5):e0197603. doi: 10.1371/journal.pone.0197603. eCollection 2018.
185 Disorders of Mechanisms of Calcium Metabolism Control as Potential Risk Factors of Prostate Cancer.Curr Med Chem. 2017;24(38):4229-4244. doi: 10.2174/0929867324666170913102834.
186 Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential.Biomed Res Int. 2016;2016:8432759. doi: 10.1155/2016/8432759. Epub 2016 Feb 18.
187 Myopathies Related to Glycogen Metabolism Disorders.Neurotherapeutics. 2018 Oct;15(4):915-927. doi: 10.1007/s13311-018-00684-2.
188 The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism.Am J Hypertens. 2019 Apr 22;32(5):468-475. doi: 10.1093/ajh/hpz023.
189 miR?30?p inhibits H2O2induced adipogenic differentiation of MSCs by regulating RXR.Int J Mol Med. 2018 Oct;42(4):2042-2052. doi: 10.3892/ijmm.2018.3773. Epub 2018 Jul 12.
190 Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice.Reprod Toxicol. 2019 Mar;84:9-17. doi: 10.1016/j.reprotox.2018.12.003. Epub 2018 Dec 15.
191 Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1 axis regulates ER stress during high-carbohydrate feeding.Sci Rep. 2019 Oct 31;9(1):15761. doi: 10.1038/s41598-019-52339-7.
192 Controlling Obesity and Metabolic Diseases by Hydrodynamic Delivery of a Fusion Gene of Exendin-4 and 1 Antitrypsin.Sci Rep. 2019 Sep 17;9(1):13427. doi: 10.1038/s41598-019-49757-y.
193 SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.EBioMedicine. 2018 Oct;36:347-357. doi: 10.1016/j.ebiom.2018.09.037. Epub 2018 Sep 29.
194 Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.J Biol Chem. 2019 Feb 1;294(5):1579-1589. doi: 10.1074/jbc.RA118.005309. Epub 2018 Dec 10.
195 The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687. doi: 10.1146/annurev-pharmtox-010617-052713.
196 Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 function.Clin Sci (Lond). 2018 Jul 31;132(14):1545-1563. doi: 10.1042/CS20180148. Print 2018 Jul 31.
197 Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity.Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2705-2710. doi: 10.1073/pnas.1700997114. Epub 2017 Feb 21.
198 The Beneficial Effect of Anthocyanidin-Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High-Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions.Phytother Res. 2017 Oct;31(10):1621-1632. doi: 10.1002/ptr.5898. Epub 2017 Aug 25.
199 Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders.Cureus. 2018 Mar 28;10(3):e2382. doi: 10.7759/cureus.2382.
200 Prenatal Growth Patterns and Birthweight Are Associated With Differential DNA Methylation and Gene Expression of Cardiometabolic Risk Genes in Human Placentas: A Discovery-Based Approach.Reprod Sci. 2018 Apr;25(4):523-539. doi: 10.1177/1933719117716779. Epub 2017 Jul 11.
201 Impact of genotype on neutropenia in a large cohort of Serbian patients with glycogen storage disease type Ib.Eur J Med Genet. 2020 Mar;63(3):103767. doi: 10.1016/j.ejmg.2019.103767. Epub 2019 Sep 16.
202 Intestinal SGLT1 in metabolic health and disease.Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G887-98. doi: 10.1152/ajpgi.00068.2016. Epub 2016 Mar 24.
203 Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and non-alcoholic fatty liver disease in mice.Br J Pharmacol. 2020 Jan;177(2):239-253. doi: 10.1111/bph.14859. Epub 2019 Nov 12.
204 Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):645-659. doi: 10.1111/bcpt.13073. Epub 2018 Jul 26.
205 The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and -Glycosidase: a Perspective for Metabolic Disorders.Appl Biochem Biotechnol. 2020 Feb;190(2):437-447. doi: 10.1007/s12010-019-03099-7. Epub 2019 Aug 5.
206 Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):19-25. doi: 10.1161/ATVBAHA.117.310292. Epub 2017 Nov 30.
207 Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.Cell. 2018 Aug 9;174(4):831-842.e12. doi: 10.1016/j.cell.2018.06.031. Epub 2018 Jul 26.
208 Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1189-1194. doi: 10.1073/pnas.1620506114. Epub 2017 Jan 17.
209 Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.
210 Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice.Atherosclerosis. 2019 Feb;281:47-55. doi: 10.1016/j.atherosclerosis.2018.12.020. Epub 2018 Dec 30.
211 Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling.Front Physiol. 2018 Jul 9;9:873. doi: 10.3389/fphys.2018.00873. eCollection 2018.
212 Alginate oligosaccharide (AOS) improves immuno-metabolic systems by inhibiting STOML2 overexpression in high-fat-diet-induced obese zebrafish.Food Funct. 2019 Aug 1;10(8):4636-4648. doi: 10.1039/c9fo00982e. Epub 2019 Jul 10.
213 Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.Cell Mol Neurobiol. 2020 Mar;40(2):239-255. doi: 10.1007/s10571-019-00743-y. Epub 2019 Oct 23.
214 Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis.Hum Mol Genet. 2017 Jul 15;26(14):2719-2731. doi: 10.1093/hmg/ddx159.
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