Details of Disease | DrugMAP

General Information of Disease (ID: DISODKU2)

Disease Name	Inflammatory bowel disease 25
Synonyms	inflammatory bowel disease, early-onset, autosomal recessive; inflammatory bowel disease 25, autosomal recessive; inflammatory bowel disease 25, early onset, autosomal recessive; IL10RB inflammatory bowel disease; inflammatory bowel disease type 25; IBD25; inflammatory bowel disease caused by mutation in IL10RB; early onset autosomal recessive inflammatory bowel disease 25
Definition	Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene.
Disease Hierarchy	DISB2Y7L: Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome DISGN23E: Inflammatory bowel disease DISODKU2: Inflammatory bowel disease 25
Disease Identifiers	MONDO ID MONDO_0012941 UMLS CUI C2675508 OMIM ID 612567 MedGen ID 393403

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL10RB	TTJTRMK	Strong	Autosomal recessive	[1]
IL10RB	TTJTRMK	Strong	Biomarker	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IL10RB	OT5AN6ZR	Strong	Autosomal recessive	[1]
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References

1	Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009 Nov 19;361(21):2033-45. doi: 10.1056/NEJMoa0907206. Epub 2009 Nov 4.
2	Phenotypic and Genotypic Characterisation of Inflammatory Bowel Disease Presenting Before the Age of 2 years.J Crohns Colitis. 2017 Jan;11(1):60-69. doi: 10.1093/ecco-jcc/jjw118. Epub 2016 Jun 14.