Details of Disease

General Information of Disease (ID: DISOSL2O)

• Disease Name: Familial or sporadic hemiplegic migraine
• Synonyms: hemiplegic migraine; familial or sporadic hemiplegic migraine; Hemiplegic Migraine
• Definition: Hemiplegic migraine (HM) is a rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. Hemiplegic migraine has two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM).
• Disease Hierarchy:
  DISDM7I8: Migraine with aura
  DISOSL2O: Familial or sporadic hemiplegic migraine

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATP1A2	TT5B6HJ	Supportive	Autosomal dominant	[1]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
CACNA1A	DTYKGPB	Supportive	Autosomal dominant	[1]
SCN1A	DTN0M1I	Supportive	Autosomal dominant	[1]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATP1A2	OTCF8OWW	Supportive	Autosomal dominant	[1]
CACNA1A	OTY08SIX	Supportive	Autosomal dominant	[1]
PRRT2	OTCJUBDO	Supportive	Autosomal dominant	[2]
SCN1A	OTJ9ZTYI	Supportive	Autosomal dominant	[1]

References

• [1] Familial Hemiplegic Migraine. 2001 Jul 17 [updated 2021 Apr 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews(?) [Internet]. Seattle (WA): University of Washington, Seattle; 1993C2024.
• [2] PRRT2 mutations cause hemiplegic migraine. Neurology. 2012 Nov 20;79(21):2122-4. doi: 10.1212/WNL.0b013e3182752cb8. Epub 2012 Oct 17.