Details of Disease

General Information of Disease (ID: DISDM7I8)

Disease Name Migraine with aura
Synonyms classic migraine
Definition A migraine disorder characterized by episodes that are preceded by focal neurological symptoms.
Disease Hierarchy
DISFCQTG: Migraine disorder
DISDM7I8: Migraine with aura
Disease Identifiers
MONDO ID
MONDO_0005475
MESH ID
D020325
UMLS CUI
C0154723
MedGen ID
57822
HPO ID
HP:0002077
SNOMED CT ID
4473006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 13 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ASIC1 TTRJYB6 Strong Biomarker [1]
CACNA1E TTYRP0M Strong Genetic Variation [2]
CSNK1D TTH30UI Strong Genetic Variation [3]
DBH TTYIP79 Strong Biomarker [4]
DDC TTN451K Strong Genetic Variation [5]
EDNRA TTKRD0G Strong Genetic Variation [6]
FSHR TTZFDBT Strong Genetic Variation [7]
HTR2B TT0K1SC Strong Genetic Variation [5]
KCNK18 TTHT87J Strong Genetic Variation [8]
MMP16 TTNP4CU Strong Genetic Variation [9]
NOTCH3 TTVX7IA Strong Genetic Variation [10]
SCN1A TTANOZH Strong Biomarker [11]
TRPV3 TT946IA Strong Genetic Variation [12]
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⏷ Show the Full List of 13 DTT(s)
This Disease Is Related to 8 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADARB2 OTDJKS39 Strong Genetic Variation [13]
CASQ1 OTAY8WOO Strong Biomarker [14]
CSAD OT3I2G0A Strong Biomarker [15]
NEDD4L OT1B19RU Strong Genetic Variation [13]
PRDM16 OT0BGA27 Strong Genetic Variation [16]
SPTAN1 OT6VY3A3 Strong Altered Expression [17]
TSPAN2 OTTDPQF1 Strong Genetic Variation [9]
TSPAN33 OTH6C0WU Strong Biomarker [18]
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⏷ Show the Full List of 8 DOT(s)

References

1 Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.Ann Neurol. 2012 Oct;72(4):559-63. doi: 10.1002/ana.23653.
2 Possible Involvement of the CACNA1E Gene in Migraine: A Search for Single Nucleotide Polymorphism in Different Clinical Phenotypes.Headache. 2017 Jul;57(7):1136-1144. doi: 10.1111/head.13107. Epub 2017 Jun 1.
3 Casein kinase i mutations in familial migraine and advanced sleep phase.Sci Transl Med. 2013 May 1;5(183):183ra56, 1-11. doi: 10.1126/scitranslmed.3005784.
4 New genetic evidence for involvement of the dopamine system in migraine with aura.Hum Genet. 2009 Apr;125(3):265-79. doi: 10.1007/s00439-009-0623-z. Epub 2009 Jan 17.
5 Association study of the serotoninergic system in migraine in the Spanish population.Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):177-84. doi: 10.1002/ajmg.b.30972.
6 Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura.Cephalalgia. 2009 Nov;29(11):1224-31. doi: 10.1111/j.1468-2982.2009.01855.x. Epub 2009 Apr 9.
7 Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine.Headache. 2008 Nov-Dec;48(10):1438-50. doi: 10.1111/j.1526-4610.2008.01294.x.
8 Family studies to find rare high risk variants in migraine.J Headache Pain. 2017 Dec;18(1):32. doi: 10.1186/s10194-017-0729-y. Epub 2017 Mar 2.
9 Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura.Cephalalgia. 2015 Aug;35(9):776-82. doi: 10.1177/0333102414557841. Epub 2014 Nov 11.
10 Recognition of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Two Oligosymptomatic Sisters with Low CADASIL Scale Scores and a Venous Dysplasia: Report of a Novel Greek Family.J Stroke Cerebrovasc Dis. 2018 Sep;27(9):e191-e195. doi: 10.1016/j.jstrokecerebrovasdis.2018.04.002. Epub 2018 Apr 26.
11 The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.Cephalalgia. 2018 Oct;38(12):1849-1863. doi: 10.1177/0333102418761041. Epub 2018 Feb 27.
12 SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population.Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):94-103. doi: 10.1002/ajmg.b.32007. Epub 2011 Dec 7.
13 Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nat Genet. 2013 Aug;45(8):912-917. doi: 10.1038/ng.2676. Epub 2013 Jun 23.
14 Association analysis of chromosome 1 migraine candidate genes.BMC Med Genet. 2007 Aug 29;8:57. doi: 10.1186/1471-2350-8-57.
15 Familial hemiplegic migraine.Neurotherapeutics. 2007 Apr;4(2):274-84. doi: 10.1016/j.nurt.2007.01.008.
16 Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.Headache. 2020 Jan;60(1):71-80. doi: 10.1111/head.13670. Epub 2019 Sep 26.
17 Identification of biomarkers associated with migraine with aura.Neurosci Res. 2009 May;64(1):104-10. doi: 10.1016/j.neures.2009.02.001. Epub 2009 Feb 13.
18 Vulnerability to Infarction During Cerebral Ischemia in Migraine Sufferers.Stroke. 2018 Mar;49(3):573-578. doi: 10.1161/STROKEAHA.118.020554. Epub 2018 Feb 19.