Details of Disease

General Information of Disease (ID: DISOZ01W)

• Disease Name: Recurrent malignant glioma
• Synonyms: GLM2; PTEN malignant glioma; glioma susceptibility 2; malignant glioma caused by mutation in PTEN; glioma susceptibility type 2
• Disease Class: 2A00: Brain cancer
• Definition: Any malignant glioma in which the cause of the disease is a mutation in the PTEN gene.
• Disease Hierarchy:
  DISGLS6H: Glioma susceptibility
  DISOZ01W: Recurrent malignant glioma
• ICD Code:
  ICD-11: ICD-11: 2A00.0
  ICD-9: ICD-9: 191
  Expand ICD-9: 191
• Disease Identifiers:
  MONDO ID: MONDO_0013092
  UMLS CUI: C2751642
  OMIM ID: 613028
  MedGen ID: 414431

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NEO100	DMI7SUU	Phase 1/2	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PTEN	TTEUQ4M	Limited	Autosomal dominant	[2]
PTEN	TTXJ3W7	Strong	Genetic Variation	[3]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PTEN	OTOWDUNT	Limited	Autosomal dominant	[2]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
• [3] A novel germline mutation of PTEN associated with brain tumours of multiple lineages.Br J Cancer. 2002 May 20;86(10):1586-91. doi: 10.1038/sj.bjc.6600206.