Details of Disease

General Information of Disease (ID: DISPBT1J)

• Disease Name: Poorly differentiated thyroid gland carcinoma
• Synonyms: poorly differentiated thyroid cancer; insular carcinoma; poorly differentiated thyroid gland carcinoma; poorly differentiated thyroid carcinoma; thyroid gland poorly differentiated carcinoma; poorly differentiated thyroid gland cancer; poorly differentiated carcinoma of the thyroid gland; poorly differentiated carcinoma of thyroid gland
• Definition: An adenocarcinoma arising from the thyroid gland showing only limited evidence of follicular cell differentiation. Microscopically, the adenocarcinoma cells are arranged in insular, solid, and trabecular patterns. There is associated necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete or partial surgical removal of the tumor, and the degree of response to radioactive iodine therapy (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon 2004)
• Disease Hierarchy:
  DIS3IHTY: Adenocarcinoma
  DISPBT1J: Poorly differentiated thyroid gland carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0006382
  UMLS CUI: C1266050
  MedGen ID: 266094
  SNOMED CT ID: 128673009

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TG	OT3ELHIJ	Strong	Altered Expression	[1]
PSME3	OTSTC4YY	Definitive	Altered Expression	[2]

References

• [1] Poorly Differentiated Thyroid Carcinoma Patients with Detectable Thyroglobulin Levels after Initial Treatment Show an Increase in Mortality and Disease Recurrence.Eur Thyroid J. 2018 Nov;7(6):313-318. doi: 10.1159/000491996. Epub 2018 Aug 21.
• [2] REG is a strong candidate for the regulation of cell cycle, proliferation and the invasion by poorly differentiated thyroid carcinoma cells.Braz J Med Biol Res. 2012 May;45(5):459-65. doi: 10.1590/s0100-879x2012007500035. Epub 2012 Mar 15.