Details of Disease

General Information of Disease (ID: DISPPN0O)

• Disease Name: Musculoskeletal disorder
• Synonyms: musculoskeletal disorder; musculoskeletal system disorder; musculoskeletal system disease or disorder; musculoskeletal system disease; musculoskeletal disease; disorder of musculoskeletal system; disease or disorder of musculoskeletal system; disease of musculoskeletal system
• Disease Class: FA00-FC0Z: Musculoskeletal disorder
• Definition: A disease involving the musculoskeletal system.
• Disease Hierarchy:
  DISH7H5I: Human disease
  DISPPN0O: Musculoskeletal disorder
• ICD Code:
  ICD-11: ICD-11: FA00-FC0Z
  ICD-10: ICD-10: M00-M99
  Expand ICD-11: '15
• Disease Identifiers:
  MONDO ID: MONDO_0002081
  MESH ID: D009140
  UMLS CUI: C0026857
  MedGen ID: 6471
  SNOMED CT ID: 928000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Carisoprodol	DMWR1JC	Approved	Small molecular drug	[1]
Chymopapain	DMYOE0R	Approved	Small molecular drug	[2]
Methocarbamol	DMM4WBX	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lanperisone	DM4EGPN	Phase 3	Small molecular drug	[4]
OrthoDerm	DMZDPEF	Phase 2	Small molecular drug	[5]
LGD-4033	DMP59HI	Phase 1	NA	[6]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SA-20896	DMDBCJS	Investigative	NA	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PTH1R	TTFPD47	Limited	Biomarker	[8]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
COL5A1	OT24078H	Limited	Genetic Variation	[9]
TRAT1	OTMPUNPD	Limited	Biomarker	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7610).
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6829).
• [4] Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
• [5] ClinicalTrials.gov (NCT00447928) Phase II Dose-Ranging Study of OrthoDerm Patch for Patients With Tennis Elbow. U.S. National Institutes of Health.
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030373)
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [8] Handling Parathormone Receptor Type 1 in Skeletal Diseases: Realities and Expectations of Abaloparatide.Trends Endocrinol Metab. 2019 Oct;30(10):756-766. doi: 10.1016/j.tem.2019.07.014. Epub 2019 Aug 11.
• [9] The BstUI and DpnII Variants of the COL5A1 Gene Are Associated With Tennis Elbow.Am J Sports Med. 2015 Jul;43(7):1784-9. doi: 10.1177/0363546515578661. Epub 2015 Apr 20.
• [10] Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases.Pharmacol Ther. 2018 May;185:12-25. doi: 10.1016/j.pharmthera.2017.10.020. Epub 2017 Oct 31.