Details of Disease | DrugMAP

General Information of Disease (ID: DISQEME2)

Disease Name	Mucocutaneous leishmaniasis
Synonyms	New World cutaneous leishmaniasis; American cutaneous leishmaniasis; mucocutaneous leishmaniasis, (American); mucocutaneous leishmaniasis, American; American mucocutaneous leishmaniasis; cutaneous leishmaniasis, American
Definition	The most common form of leishmaniasis that is transmitted through the bite of female phlebotomine sand flies or after exposure to leishmania parasites. It is characterized by skin lesions at the site of insect bite which typically develop within weeks or months after exposure. The lesions typically progress from small papules to open sores with raised borders and central ulcers which can be covered with scales or crust.
Disease Hierarchy	DISABTW7: Leishmaniasis DISQEME2: Mucocutaneous leishmaniasis
Disease Identifiers	MONDO ID MONDO_0005859 UMLS CUI C1328252 MedGen ID 233065 SNOMED CT ID 721813000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LMLN	OTQF0JPY	Limited	Altered Expression	[1]
FLI1	OT0EV3LX	moderate	Altered Expression	[2]
CLEC4D	OTT7X1UC	Strong	Biomarker	[3]
GZMA	OT43R33L	Strong	Altered Expression	[4]
------------------------------------------------------------------------------------

References

1	AIM2 inflammasome is associated with disease severity in tegumentary leishmaniasis caused by Leishmania (V.) braziliensis.Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12435. Epub 2017 May 29.
2	Analysis of expression of FLI1 and MMP1 in American cutaneous leishmaniasis caused by Leishmania braziliensis infection.Infect Genet Evol. 2017 Apr;49:212-220. doi: 10.1016/j.meegid.2017.01.018. Epub 2017 Jan 21.
3	Cloning and characterization of the Leishmania (Viannia) braziliensis Hsp70 gene. Diagnostic use of the C-terminal fragment rLb70(513-663).J Parasitol. 2003 Apr;89(2):372-8. doi: 10.1645/0022-3395(2003)089[0372:CACOTL]2.0.CO;2.
4	In Situ Cellular Response Underlying Successful Treatment of Mucosal Leishmaniasis with a Combination of Pentavalent Antimonial and Pentoxifylline.Am J Trop Med Hyg. 2019 Aug;101(2):392-401. doi: 10.4269/ajtmh.19-0139.