Details of Disease

General Information of Disease (ID: DISQOL9F)

• Disease Name: Poison intoxication
• Disease Class: NE6Z: Unspecific substance harmful effect
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISQOL9F: Poison intoxication
• ICD Code:
  ICD-11: ICD-11: NE6Z
  ICD-10: ICD-10: T88.7

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 12 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AST-120	DM718MD	Approved	Small molecular drug	[1]
Atropine	DMEN6X7	Approved	Small molecular drug	[2]
Dimercaprol	DMID0FJ	Approved	Small molecular drug	[1]
EchiTAb	DMS2XEF	Approved	NA	[1]
Ipecac	DMLZTP9	Approved	NA	[1]
Latrodectus antivenin	DMGWKGW	Approved	NA	[1]
Micrurus fulvius antivenin	DMU0G09	Approved	NA	[1]
MK-8616	DMJRDGC	Approved	Small molecular drug	[3]
Polyvalent crotalid antivenin ovine fab	DM5GM8L	Approved	NA	[1]
Serpacwa	DMGHE4E	Approved	NA	[1]
Sodium thiosulfate	DMYBCBX	Approved	Small molecular drug	[1]
ViperaTAb	DMOWHZW	Approved	NA	[1]

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Analatro	DMTZ25G	Phase 3	NA	[4]
Anascorp	DMF1JDJ	Phase 3	NA	[5]
Anavip	DMZHQTN	Phase 3	NA	[6]
PRT-105	DMY0F16	Phase 1	NA	[7]
PRX-105	DMWT8RI	Phase 1	NA	[8]

This Disease is Treated as An Indication in 3 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PolongaTab	DMFSY68	Discontinued in Preregistration	NA	[9]
TriTAb	DM2PNKH	Discontinued in Phase 2	NA	[10]
Viperfav	DMAYPYP	Terminated	NA	[12]

This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CM-2501	DMEJ4IN	Preclinical	NA	[11]

This Disease is Treated as An Indication in 8 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Anti-ricin mabs	DMHO720	Investigative	Monoclonal antibody	[13]
Aspartame	DMPPQOE	Investigative	Small molecular drug	[1]
ETHOXY-IDAZOXAN	DMNOTH5	Investigative	Small molecular drug	[14]
HI-6	DMWUJVR	Investigative	Small molecular drug	[13]
INP-03	DMCEVTT	Investigative	NA	[13]
MMB-4	DMUL4PE	Investigative	Small molecular drug	[15]
Recombinant human butyrylcholinesterase	DMM3465	Investigative	NA	[16]
Snake venom antisera	DMVXJPS	Investigative	NA	[13]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 320).
• [3] ClinicalTrials.gov (NCT01965067) Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex. U.S. National Institutes of Health.
• [4] ClinicalTrials.gov (NCT00657540) Black Widow Spider Antivenin for Patients With Systemic Latrodectism. U.S. National Institutes of Health.
• [5] ClinicalTrials.gov (NCT01599936) Open Label Clinical Trial of Alacramyn in Pediatric Patients With Scorpion Sting Envenomation. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT00636116) Phase 3 Multicenter Comparative Study to Confirm Safety and Effectiveness of the F(ab)2 Antivenom Anavip.. U.S. National Institutes of Health.
• [7] Biologics Research Pushing Frontiers of Science With More Than 900 Medicines and Vaccines in Development. Pharmaceutical Research and Manufacturers of America report. 2013.
• [8] ClinicalTrials.gov (NCT01093859) An Exploratory Phase 1 Microdose Study of PRX-105. U.S. National Institutes of Health.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010949)
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010203)
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023403)
• [12] Asp Viper (Vipera aspis) Envenomation: Experience of the Marseille Poison Centre from 1996 to 2008. Toxins (Basel) 2009 December; 1(2): 100-112.
• [13] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [14] Discriminative stimulus properties of ethoxy idazoxan. J Psychopharmacol. 1995 Jan;9(3):228-33.
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
• [16] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471).