Details of the Drug

General Information of Drug (ID: DMWT8RI)

Drug Name
PRX-105
Synonyms
Acetylcholinesterase (poison intoxication, ProCellEx), Protalix/Hebrew University of Jerusalem; Acetylcholinesterase (poison intoxication, plant cell-expression), Protalix/Hebrew University of Jerusalem
Indication
Disease Entry ICD 11 Status REF
Poison intoxication NE6Z Phase 1 [1]
Cross-matching ID
TTD ID
D0JA7V

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Poison intoxication
ICD Disease Classification NE6Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01093859) An Exploratory Phase 1 Microdose Study of PRX-105. U.S. National Institutes of Health.
2 Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):202-9.