Details of Disease

General Information of Disease (ID: DISQQ62D)

Disease Name Humoral hypercalcemia of malignancy
Synonyms malignant hypercalcemia; hhm; mahc; malignancy associated hypercalcemia; hypercalcemia of malignancy; humoral hypercalcemia of malignancy
Definition
Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease. Symptoms include central nervous system impairment such as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function.
Disease Hierarchy
DISKQ2K7: Hypercalcaemia
DIS7GD2N: Paraneoplastic hematological syndrome
DISQQ62D: Humoral hypercalcemia of malignancy
Disease Identifiers
MONDO ID
MONDO_0043455
MESH ID
C562390
UMLS CUI
C0149911
MedGen ID
56210
SNOMED CT ID
47709007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
PTH TT6F7GZ Strong Biomarker [1]
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References

1 Calcitriol Elevation Is Associated with a Higher Risk of Refractory Hypercalcemia of Malignancy in Solid Tumors.J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1115-23. doi: 10.1210/clinem/dgz278.