Details of Disease

Disease Name

Hyperoxaluria

Disease Class

5C51: Inborn carbohydrate metabolism error

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISRIYLK: Hyperoxaluria

ICD-11

ICD-11: 5C51.2

Expand ICD-11

'5C51.2Z

Disease Identifiers

MESH ID

D006959

MedGen ID

43782

HPO ID

HP:0003159

SNOMED CT ID

3.68E+14

General Information of Disease (ID: DISRIYLK)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lumasiran	DMEBQAO	Approved	Small interfering RNA	[1]
Nedosiran	DMCHWX1	Approved	Small interfering RNA	[2]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Oxabact	DMW8QY1	Phase 3	NA	[3]
Reloxaliase	DMOWINT	Phase 3	Protein	[4]
Oxazyme	DMTJ139	Phase 1/2	Small molecular drug	[5]
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This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ALTU-237	DMS5C06	Discontinued in Phase 1	NA	[6]
AMT-030	DMD82LM	Terminated	NA	[7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2	ClinicalTrials.gov (NCT04580420) Safety & Efficacy of DCR-PHXC in Patients With PH1/2 and ESRD (PHYOX7). U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT03938272) An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria (ePHex-OLE). U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT03847090) Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria (URIROX-2). U.S. National Institutes of Health.
5	ClinicalTrials.gov (NCT01127087) Oxazyme in Patients With Hyperoxaluria. U.S. National Institutes of Health.
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020198)
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024084)