Details of Disease

General Information of Disease (ID: DISSP87T)

Disease Name	Giant cell arteritis
Synonyms	polymyalgia rheumatica; Horton's temporal arteritis; Horton's giant cell arteritis; Hortons syndrome; Hortons disease; cranial arteritis; arteritis temporalis; GCA; arteritis cranialis; Horton's arteritis; temporal arteritis; temporal artery inflammation; Horton disease; Giant Cell Arteritis; inflammation of temporal artery; Horton's disease; giant cell arteritis
Disease Class	4A44: Vasculitis
Definition	A large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.
Disease Hierarchy	DISWD40R: Disease DISSPE2S: Granulomatous angiitis DIS3VCZB: Central nervous system vasculitis DISSP87T: Giant cell arteritis
ICD Code	ICD-11 ICD-11: 4A44.2 ICD-10 ICD-10: M31.5, M31.6 Expand ICD-11 '4A44.2 Expand ICD-10 'M31.5; 'M31.6
Disease Identifiers	MONDO ID MONDO_0008538 MESH ID D013700 UMLS CUI C1956391 OMIM ID 187360 MedGen ID 365495 Orphanet ID 397 SNOMED CT ID 400130008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Tocilizumab	DM7J6OR	Approved	Monoclonal antibody	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Resveratrol	DM3RWXL	Phase 3	Small molecular drug	[2]
Sirukumab	DMK8AQP	Phase 3	Monoclonal antibody	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PLG	TTP86E2	Strong	Genetic Variation	[3]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
P4HA2	DE5EGK0	Strong	Genetic Variation	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PTPN22	OTDCNTC3	Strong	SusceptibilityMutation	[4]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.Am J Hum Genet. 2017 Jan 5;100(1):64-74. doi: 10.1016/j.ajhg.2016.11.013. Epub 2016 Dec 29.
4	Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis.Ann Rheum Dis. 2013 Nov;72(11):1882-1886. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.