Details of Disease

General Information of Disease (ID: DISSTKBS)

• Disease Name: Exercise-induced hyperinsulinism
• Synonyms: hyperinsulinemic hypoglycemia, familial, 7; hyperinsulinemic hypoglycemia familial 7; hyperinsulinemic hypoglycemia, exercise-induced; hyperinsulinemic hypoglycemia exercise-induced; exercise induced hyperinsulinemic hypoglycemia; HHF7; hyperinsulinism due to SLC16A1 deficiency; exercise-induced hyperinsulinemic hypoglycemia; monocarboxylate transporter 1 hyperinsulinism; hyperinsulinism due to monocarboxylate transporter 1 deficiency; hyperinsulinemic hypoglycemia, familial, type 7; EIHI; MCT1 hyperinsulinism
• Definition: Exercise-induced hyperinsulinism (EIHI) is a form of diazoxide-sensitive diffuse hyperinsulinism (DHI) characterized by episodes of hypoglycemia induced by exercise due to an inappropriate lactate and pyruvate sensitivity in pancreatic beta-cells.
• Disease Hierarchy:
  DISOEYSO: Diazoxide-sensitive diffuse hyperinsulinism
  DIS6ZIDS: Disorder of carbohydrate transmembrane transport and absorption
  DISSTKBS: Exercise-induced hyperinsulinism
• Disease Identifiers:
  MONDO ID: MONDO_0012396
  MESH ID: C538376
  UMLS CUI: C1864902
  OMIM ID: 610021
  MedGen ID: 351246
  Orphanet ID: 165991
  SNOMED CT ID: 715830008

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC16A1	TTN1J82	Strong	Biomarker	[1]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC16A1	DT342ZG	Supportive	Autosomal dominant	[1]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SLC16A1	OTW1UTZ7	Supportive	Autosomal dominant	[1]

References

• [1] Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet. 2007 Sep;81(3):467-74. doi: 10.1086/520960. Epub 2007 Jul 26.