Details of Disease

General Information of Disease (ID: DIST2NIJ)

• Disease Name: Gynecologic cancer
• Synonyms: malignant tumour of the female reproductive system; malignant tumour of female reproductive system; malignant tumor of the female reproductive system; malignant tumor of female reproductive system; malignant neoplasm of the female reproductive system; malignant neoplasm of female reproductive system; malignant neoplasm of female reproductive organ; malignant neoplasm of female genital organ; malignant gynecologic tumour; malignant gynecologic tumor; malignant gynecologic neoplasm; malignant female reproductive system tumour; malignant female reproductive system tumor; malignant female reproductive system neoplasm; malignant female reproductive organ neoplasm; gynecologic cancer; female reproductive organ cancer; female reproductive cancer; cancer of female reproductive organ
• Disease Class: 2F33-2F76: Gynecologic cancer
• Definition: A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma.
• Disease Hierarchy:
  DIS84532: Reproductive system cancer
  DISAT1Z9: Advanced cancer
  DISDVNRY: Female reproductive system neoplasm
  DIST2NIJ: Gynecologic cancer
• ICD Code: ICD-11: ICD-11: 2F33-2F76
• Disease Identifiers:
  MONDO ID: MONDO_0001416
  UMLS CUI: C0699889
  MedGen ID: 195944

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Abexinostat	DM91LGU	Phase 3	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MUC16	TTC1PS3	Limited	Biomarker	[2]
OGFR	TT6IEYX	Strong	Biomarker	[3]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
UGT1A10	DEL5N6Y	Limited	Biomarker	[4]
UGT1A4	DELOY3P	Limited	Biomarker	[4]
UGT1A8	DE2GB8N	Limited	Biomarker	[4]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CTU1	OTNTM9D1	Limited	Genetic Variation	[5]
PEG3	OTHQW98S	moderate	Altered Expression	[6]
AMT	OTQYEWZQ	Strong	Biomarker	[7]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Poor concordance between CA-125 and RECIST at the time of disease progression in patients with platinum-resistant ovarian cancer: analysis of the AURELIA trial.Ann Oncol. 2016 Aug;27(8):1505-10. doi: 10.1093/annonc/mdw238. Epub 2016 Jul 11.
• [3] Prospective oncotarget for gynecological cancer: Opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.Int Immunopharmacol. 2019 Oct;75:105723. doi: 10.1016/j.intimp.2019.105723. Epub 2019 Aug 9.
• [4] Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study.Oncology. 2009;76(5):315-21. doi: 10.1159/000209335. Epub 2009 Mar 20.
• [5] JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations.Sci Rep. 2013 Oct 24;3:3042. doi: 10.1038/srep03042.
• [6] Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.Gynecol Oncol. 2005 Oct;99(1):126-34. doi: 10.1016/j.ygyno.2005.05.036.
• [7] Effects of Anma therapy (Japanese massage) on health-related quality of life in gynecologic cancer survivors: A randomized controlled trial.PLoS One. 2018 May 3;13(5):e0196638. doi: 10.1371/journal.pone.0196638. eCollection 2018.