Details of Disease

General Information of Disease (ID: DISTRF6P)

• Disease Name: Eosinophilic pneumonia
• Synonyms: pneumonia, eosinophilic; eosinophilic pneumonia
• Definition: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
• Disease Hierarchy:
  DIS8EF3M: Pneumonia
  DISTRF6P: Eosinophilic pneumonia
• Disease Identifiers:
  MONDO ID: MONDO_0005749
  MESH ID: D011657
  UMLS CUI: C1527407
  MedGen ID: 282904
  HPO ID: HP:0032071

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LGMN	TTPTWV5	Strong	Genetic Variation	[1]
MYD88	TTB6Q2O	Strong	Biomarker	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCL16	OTOOQI1F	Strong	Altered Expression	[3]

References

• [1] Drug-induced eosinophilic pneumonia: A review of 196 case reports.Medicine (Baltimore). 2018 Jan;97(4):e9688. doi: 10.1097/MD.0000000000009688.
• [2] MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens.Mucosal Immunol. 2018 May;11(3):796-810. doi: 10.1038/mi.2017.84. Epub 2017 Oct 25.
• [3] Elevated concentrations of liver-expressed chemokine/CC chemokine ligand 16 in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia.Int Arch Allergy Immunol. 2009;150(3):282-90. doi: 10.1159/000222681. Epub 2009 Jun 4.