Details of Disease

Disease Name

Critical limb ischemia

Disease Class

BD4Z: Chronic arterial occlusive disease

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISTT0QZ: Critical limb ischemia

ICD-11

ICD-11: BD4Y

ICD-9

ICD-9: 459.89

Expand ICD-11

'BD4Y

Expand ICD-9

459.89

General Information of Disease (ID: DISTT0QZ)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Treprostinil	DMTIQF3	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Beperminogene perplasmid	DM6RWBN	Phase 3	NA	[2]
PLX-PAD cell therapy	DMW0IRA	Phase 3	NA	[2]
ACP-01	DM15WLR	Phase 2	NA	[2]
CLBS12	DMOCGTL	Phase 2	Cell therapy	[3]
ASCT01	DMA5JS1	Phase 1/2	NA	[2]
AAV-hTERT	DMV1J21	Phase 1	Gene therapy	[4]
ALO 212	DM8VNDG	Phase 1	NA	[5]
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⏷ Show the Full List of 7 Drug(s)

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Riferminogene pecaplasmid	DMBKN4P	Discontinued in Phase 3	NA	[6]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AL0-212	DMBRCMW	Investigative	NA	[7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Treprostinil FDA Label
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT02501018) Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI). U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT04110964) Evaluation of Safety and Tolerability of Libella Gene Therapy (LGT) for Critical Limb Ischemia: AAV- hTERT. U.S.National Institutes of Health.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028945)
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011879)
7	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.