Details of Disease

General Information of Disease (ID: DISTTJES)

Disease Name	Ocular infection
Synonyms	ocular infections; infection, eye; infections, eye; ocular infection; infections, ocular; infection, ocular; eye infection
Disease Class	1F00: Herpes simplex infection
Definition	An infectious process affecting any part of the eye. Causes include viruses and bacteria. Symptoms include itching and discomfort in the eye, watery eyes, eye pain and discharge, and blurring vision. Representative examples include pink eye, blepharitis, and trachoma.
Disease Hierarchy	DISB52BH: Eye disorder DISEM33Q: Infectious disease DISTTJES: Ocular infection
ICD Code	ICD-11 ICD-11: 1F00.1 ICD-10 ICD-10: H00-H59
Disease Identifiers	MONDO ID MONDO_0043885 MESH ID D015817 UMLS CUI C0015403 MedGen ID 41934 SNOMED CT ID 128351009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DCN01	DMUFPL6	Phase 2	NA	[1]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ISV-102	DM32GL4	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DFFA	TTYVQ9C	moderate	Genetic Variation	[3]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ART4	OTTV2J54	Limited	Biomarker	[4]
DOK1	OTGVRLW6	Limited	Biomarker	[4]
DOK2	OTIJ38UF	Limited	Biomarker	[4]
EIPR1	OTNQKNL3	moderate	Biomarker	[5]
FAM20C	OTW5YZ7X	moderate	Altered Expression	[6]
ND4	OT4RQVAA	moderate	Genetic Variation	[7]
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⏷ Show the Full List of 6 DOT(s)

References

1	ClinicalTrials.gov (NCT01853722) A Phase 2, Open-Label, Randomized, Parallel Group, Placebo-Controlled, Single-Center Study to Assess Anti-microbial Efficacy and Safety of DCN01 Compared to Unisol Following Topical Periocular Administration in Healthy Volunteers. U.S. National Institutes of Health.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	Staphylococcus epidermidis with the icaA?icaD?IS256?genotype and protein or protein/extracellular-DNA biofilm is frequent in ocular infections.J Med Microbiol. 2013 Oct;62(Pt 10):1579-1587. doi: 10.1099/jmm.0.055210-0. Epub 2013 Jul 16.
4	Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8(+) T Cells in a Murine Model of Ocular Infection.J Virol. 2017 Jul 12;91(15):e02297-16. doi: 10.1128/JVI.02297-16. Print 2017 Aug 1.
5	Evaluation of biofilm-specific antimicrobial resistance genes in Pseudomonas aeruginosa isolates in Farabi Hospital.J Med Microbiol. 2017 Jul;66(7):905-909. doi: 10.1099/jmm.0.000521. Epub 2017 Jul 19.
6	Acanthamoeba T4 and T15 genotypes associated with keratitis infections in Italy.Eur J Clin Microbiol Infect Dis. 2009 Jun;28(6):607-12. doi: 10.1007/s10096-008-0682-4. Epub 2008 Dec 18.
7	Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.JAMA Ophthalmol. 2014 Apr 1;132(4):409-20. doi: 10.1001/jamaophthalmol.2013.7630.