Details of Disease | DrugMAP

General Information of Disease (ID: DISTUGFF)

Disease Name	Vitamin C deficiency
Synonyms	L-gulonolactone oxidase, nonfunctional; scorbutus; L-gulonolactone oxidase pseudogene; vitamin C, inability to synthesize; Gulo, nonfunctional; hypoascorbemia; vitamin C, inability to synthesise; vitamin C deficiency; deficiency of vitamin C; scurvy; ascorbic acid deficiency
Disease Class	5B55-5B5F: Vitamin deficiency
Definition	A condition that develops in people who do not consume an adequate amount of vitamin C in their diet. Although scurvy is relatively rare in the United States, it continues to be a problem in malnourished populations around the world (such as impoverished, underdeveloped third world countries). Early features of the condition include general weakness, fatigue and aching limbs. If left untreated, more serious problems can develop such as anemia, gum disease, and skin hemorrhages. Symptoms generally develop after at least 3 months of severe or total vitamin C deficiency. Scurvy can be cured with vitamin C supplements taken by mouth. Once recovery is complete, dietary modifications to ensure the 'recommended daily intake' of vitamin C is reached will prevent relapse. Except in the case of severe dental disease, permanent damage from scurvy does not usually occur.\|An argument can be made that Vitamin C deficiency is a genetic disease shared by all humans, due to our loss of the GULO gene. See OMIM for discussion. Here we choose not to treat as genetic.
Disease Hierarchy	DISWRYYA: Carbohydrate metabolism disease DISD07I9: Vitamin deficiency DISTVTFI: Disorder of organic acid metabolism DISTUGFF: Vitamin C deficiency
ICD Code	ICD-11 ICD-11: 5B56 ICD-10 ICD-10: E54, E64.2 ICD-9 ICD-9: 267 Expand ICD-11 '5B56 Expand ICD-10 'E54; 'E64.2 Expand ICD-9 267
Disease Identifiers	MONDO ID MONDO_0009412 MESH ID D012614 UMLS CUI C0036474 OMIM ID 240400 MedGen ID 20684

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vitamin C	DMXJ7O8	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4781).