Details of Disease

General Information of Disease (ID: DISD07I9)

• Disease Name: Vitamin deficiency
• Synonyms: deficiencies, vitamin; Avitaminoses; vitamin deficiencies; deficiency, vitamin; vitamin deficiency; avitaminosis; vitamin deficiency disorder
• Disease Class: 5B50-5B71: Nutritional deficiency
• Definition: A disorder that is caused by the deficiency of a vitamin. The deficiency may result from either suboptimal vitamin intake or conditions that prevent the vitamin's use or absorption in the body. Representative examples include beriberi caused by thiamine deficiency, scurvy caused by vitamin C deficiency, and rickets caused by vitamin D deficiency.
• Disease Hierarchy:
  DIS1UUNY: Malnutrition
  DISD07I9: Vitamin deficiency
• ICD Code:
  ICD-11: ICD-11: 5B55-5B71
  ICD-10: ICD-10: E56.9
  Expand ICD-11: '5B7Z
  Expand ICD-10: 'E56.9
• Disease Identifiers:
  MONDO ID: MONDO_0024298
  MESH ID: D001361
  UMLS CUI: C1510471
  MedGen ID: 267607
  SNOMED CT ID: 85670002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 11 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Beta-carotene	DM0RXBT	Approved	Small molecular drug	[1]
Cholecalciferol	DMGU74E	Approved	Small molecular drug	[2]
Cyanocobalamin	DMYY0AJ	Approved	NA	[3]
Ergocalciferol	DMHO0AR	Approved	Small molecular drug	[4]
Folic Acid	DMEMBJC	Approved	Small molecular drug	[5]
Pantothenic acid	DM091H2	Approved	Small molecular drug	[6]
Riboflavin	DM8YMWE	Approved	Small molecular drug	[7]
Vitamin	DMOJIN3	Approved	NA	[8]
Vitamin A	DMJ2AH4	Approved	Small molecular drug	[9]
Vitamin B3	DMQVRZH	Approved	Small molecular drug	[10]
Vitamin C	DMXJ7O8	Approved	Small molecular drug	[11]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
[3H]thiamine	DMSHW2E	Investigative	Small molecular drug	[12]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC22A7	DT0OC1Q	Strong	Biomarker	[13]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
JPH3	OTHTJO2I	Limited	Biomarker	[14]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Cholecalciferol FDA Label
• [3] Cyanocobalamin FDA Label
• [4] Ergocalciferol FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4563).
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4668).
• [7] Riboflavin FDA Label
• [8] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [9] Vitamin A FDA Label
• [10] Hydrosoluble vitamins. Handb Clin Neurol. 2014;120:891-914.
• [11] Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020 Jun 5;9:e20.
• [12] The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. AAPS J. 2021 Mar 1;23(2):35.
• [13] Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.Clin Pharmacol Ther. 2018 Nov;104(5):890-899. doi: 10.1002/cpt.1112. Epub 2018 Aug 8.
• [14] Expanding the Spectrum of Genes Involved in Huntington Disease Using a Combined Clinical and Genetic Approach.JAMA Neurol. 2016 Sep 1;73(9):1105-14. doi: 10.1001/jamaneurol.2016.2215.