Details of Disease

General Information of Disease (ID: DISUPJBC)

Disease Name Endolymphatic hydrops
Synonyms labyrinthine hydrops
Definition
An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.
Disease Hierarchy
:
DISUPJBC: Endolymphatic hydrops
Disease Identifiers
MONDO ID
MONDO_0006744
MESH ID
D018159
UMLS CUI
C0206586
MedGen ID
60183
SNOMED CT ID
2.76E+13

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
PDE4A TTZ97H5 Strong Biomarker [1]
F11 TTDM4ZU Definitive Biomarker [2]
PDE5A TTJ0IQB Definitive Biomarker [1]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AQP2 OTQLBKK6 Disputed Biomarker [3]
MLLT3 OTXH4DDG Disputed Biomarker [4]
ADD1 OTTF68DC moderate Genetic Variation [5]
PTCRA OTQTO5QZ Definitive Biomarker [2]
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References

1 Endolymphatic hydrops induced by different mechanisms responds differentially to spironolactone: a rationale for understanding the diversity of treatment responses in hydropic inner ear disease.Acta Otolaryngol. 2019 Aug;139(8):685-691. doi: 10.1080/00016489.2019.1616819. Epub 2019 May 30.
2 Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.Eur Arch Otorhinolaryngol. 2019 Apr;276(4):993-1000. doi: 10.1007/s00405-018-05267-7. Epub 2019 Jan 29.
3 Arginine Vasopressin-Aquaporin-2 Pathway-Mediated Dehydration Effects of Electroacupuncture in Guinea Pig Model of AVP-Induced Eendolymphatic Hydrops.Chin J Integr Med. 2019 Oct;25(10):763-769. doi: 10.1007/s11655-017-2411-2. Epub 2018 Jan 15.
4 Effect of aldosterone on cochlear Af9 expression and hearing in guinea pig.Acta Otolaryngol. 2017 Sep;137(9):903-909. doi: 10.1080/00016489.2017.1309681. Epub 2017 Apr 11.
5 Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Mnire's syndrome.Otol Neurotol. 2008 Sep;29(6):824-8. doi: 10.1097/MAO.0b013e318180a4b1.