Details of Disease

General Information of Disease (ID: DISVP0XW)

• Disease Name: Congenital toxoplasmosis
• Synonyms: congenital toxoplasmosis; Toxoplasma embryofetopathy; toxoplasmosis - congen.; Toxoplasma embryopathy; toxoplasmosis, congenital; mother-to-child transmission of toxoplasmosis
• Definition: Toxoplasma infection that is present from birth.
• Disease Hierarchy:
  DISYP8FH: Toxoplasmosis
  DIS2BIP8: Congenital nervous system disorder
  DIS2D2DJ: Infectious embryofetopathy
  DISF1QLJ: Central nervous system infectious disorder
  DISVP0XW: Congenital toxoplasmosis
• Disease Identifiers:
  MONDO ID: MONDO_0005715
  MESH ID: D014125
  UMLS CUI: C0040560
  MedGen ID: 52799
  Orphanet ID: 858
  SNOMED CT ID: 73893000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Sulfadiazine	DMTW3R8	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ERAP1	TT60XFL	Strong	Genetic Variation	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TBATA	OTGDMAAL	Strong	Genetic Variation	[3]

References

• [1] Sulfadiazine FDA Label
• [2] Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.Vaccine. 2010 May 21;28(23):3977-89. doi: 10.1016/j.vaccine.2010.03.028. Epub 2010 Mar 26.
• [3] The rural-urban effect on spatial genetic structure of type II Toxoplasma gondii strains involved in human congenital toxoplasmosis, France, 2002-2009.Infect Genet Evol. 2015 Dec;36:511-516. doi: 10.1016/j.meegid.2015.08.025. Epub 2015 Aug 22.