Details of Disease

General Information of Disease (ID: DISVT8B1)

• Disease Name: Itching
• Synonyms: water-induced itching; aquagenic pruritus
• Disease Class: 1F28-1G07: Itching
• Definition: Aquagenic pruritus is a conditionin which contact with water of any temperature causes intense itching, without any visible skin changes. The symptoms may begin immediately after contact and can last for an hour or more. The cause of aquagenic pruritus is unknown; however, familial cases have been described. It may be a symptom of polycythemia vera or another underlying condition. Overall, treatment is a challenge. Antihistamines, UVB phototherapy, PUVA therapy and various medications have been tried with varying degrees of success.
• Disease Hierarchy:
  DIS9YPUQ: Dermatological disease
  DISVT8B1: Itching
• ICD Code: ICD-11: ICD-11: 1F28-1G07
• Disease Identifiers:
  MONDO ID: MONDO_0021913
  UMLS CUI: C0406409
  MedGen ID: 98026
  SNOMED CT ID: 238695001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Naphazoline	DMJFZDL	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PF-04957325	DMPEZKT	Investigative	NA	[2]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259.