Details of Disease

General Information of Disease (ID: DISWWSW7)

• Disease Name: Neoplastic meningitis
• Synonyms: leptomeningeal carcinoma; leptomeningeal metastasis; meningeal metastasis; leptomeningeal carcinomatosis; carcinomatous meningitis; metastatic malignant neoplasm in the leptomeninges; meningeal carcinomatosis
• Definition: Metastatic neoplasm in which the tumor cells spread to leptomeninges (pia and arachnoid) and subarachnoid space. The most common primary tumors metastasizing to the leptomeninges are breast and lung carcinomas, melanoma, aggressive non-Hodgkin lymphoma, and acute lymphocytic leukemia.
• Disease Hierarchy:
  DIS86UK6: Metastatic malignant neoplasm
  DISWWSW7: Neoplastic meningitis
• Disease Identifiers:
  MONDO ID: MONDO_0700219
  UMLS CUI: C1704231
  MedGen ID: 352817
  SNOMED CT ID: 1155991005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cytarabine	DMZD5QR	Approved	Small molecular drug	[1]
Erlotinib	DMCMBHA	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALK	TTPMQSO	moderate	Biomarker	[3]
CEACAM5	TTY6DTE	moderate	Biomarker	[4]

References

• [1] Cytarabine FDA Label
• [2] Erlotinib FDA Label
• [3] Sequential ALK inhibitor treatment benefits patient with leptomeningeal metastasis harboring non-EML4-ALK rearrangements detected from cerebrospinal fluid: A case report.Thorac Cancer. 2020 Jan;11(1):176-180. doi: 10.1111/1759-7714.13259. Epub 2019 Nov 25.
• [4] Baseline serum/cerebrospinal fluid ratio of carcinoembryonic antigen and carbohydrate antigen series biomarkers in non-neoplastic diseases: a cross-sectional study on 224 patients.Clin Biochem. 2019 Jan;63:135-138. doi: 10.1016/j.clinbiochem.2018.11.003. Epub 2018 Nov 4.