Details of Disease

Disease Name

Tertiary syphilis

late tertiary syphilis; tertiary syphilis; late syphilis

Definition

A stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis).

Disease Hierarchy

DISJ73BS: Syphilis

DISXHT8N: Tertiary syphilis

Disease Identifiers

MONDO ID

MONDO_0004497

MESH ID

C536774

UMLS CUI

C0153188

MedGen ID

56297

SNOMED CT ID

72083004

General Information of Disease (ID: DISXHT8N)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PTER	OTBYJHDG	Strong	Biomarker	[2]
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References

1	A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature. Orthop Rev (Pavia). 2020 Jun 25;12(Suppl 1):8675.
2	Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV.Open Forum Infect Dis. 2018 Nov 30;6(1):ofy324. doi: 10.1093/ofid/ofy324. eCollection 2019 Jan.