Details of Disease

General Information of Disease (ID: DISY1VPA)

Disease Name Coxsackie virus infection
Disease Class 1D91: Enterovirus infection
Definition
A heterogeneous group of infections produced by coxsackieviruses, including herpangina, aseptic meningitis (meningitis, aseptic), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (pleurodynia, epidemic) and a serious myocarditis.
Disease Hierarchy
DISH2UDP: Enterovirus infection
DISEM33Q: Infectious disease
DISY1VPA: Coxsackie virus infection
ICD Code
ICD-11
ICD-11: 1D91
ICD-10
ICD-10: B34.1
Expand ICD-11
'1D91
Expand ICD-10
'B34.1
Disease Identifiers
MONDO ID
MONDO_0005721
MESH ID
D003384
UMLS CUI
C0010246
MedGen ID
1159
SNOMED CT ID
186658007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
OBR-5-340 DMSNG25 Investigative NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ITCH TT5SEWD Limited Biomarker [2]
SLC22A3 TTG2UMS Limited Biomarker [3]
GAD2 TT7UY6K Strong Genetic Variation [4]
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This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC22A4 DT2EG60 Limited Biomarker [3]
SLC22A5 DT3HUVD Limited Biomarker [3]
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This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
NBR1 OTVRL7J9 Limited Biomarker [5]
PLCB2 OTPAHDGO Limited Altered Expression [6]
SIVA1 OTDT0XZK Strong Biomarker [7]
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References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.Mol Med Rep. 2015 Jul;12(1):1258-64. doi: 10.3892/mmr.2015.3539. Epub 2015 Mar 24.
3 Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy. Am J Pathol. 2011 Jun;178(6):2547-59.
4 Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule.Diabetologia. 1998 Jan;41(1):40-6. doi: 10.1007/s001250050864.
5 Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection.Cell Death Differ. 2014 Sep;21(9):1432-41. doi: 10.1038/cdd.2014.58. Epub 2014 Apr 25.
6 PLC2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.Nat Commun. 2019 Feb 14;10(1):746. doi: 10.1038/s41467-019-08524-3.
7 The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.Mol Cell Biochem. 2006 Jul;287(1-2):147-55. doi: 10.1007/s11010-005-9082-6. Epub 2006 May 9.