Details of Disease

General Information of Disease (ID: DISYG7IE)

Disease Name Ventricular tachycardia, familial
Synonyms familial ventricular tachycardia; ventricular tachycardia, familial polymorphic; ventricular tachycardia, familial; ventricular tachycardia, idiopathic; hereditary ventricular tachycardia
Definition An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.
Disease Hierarchy
DISMT2VZ: Cardiogenetic disease
DISBRUSE: Acute supraventricular tachycardia
DISYG7IE: Ventricular tachycardia, familial
Disease Identifiers
MONDO ID
MONDO_0008648
MESH ID
C536334
UMLS CUI
C0340485
OMIM ID
192605
MedGen ID
83309
SNOMED CT ID
233906007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA5 DT195NK Limited Unknown [1]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
GNAI2 OTTLGRGH No Known Unknown [2]
ABCA5 OT4B9D92 Limited Unknown [1]
RYR2 OT0PF19E moderate Biomarker [3]
CASQ2 OT09MNQ8 Strong Biomarker [4]
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References

1 Family-Based Whole Genome Sequencing Identified Novel Variants in ABCA5 Gene in a Patient with Idiopathic Ventricular Tachycardia. Pediatr Cardiol. 2020 Dec;41(8):1783-1794. doi: 10.1007/s00246-020-02446-4. Epub 2020 Sep 16.
2 Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2. J Clin Invest. 1998 Jun 15;101(12):2862-8. doi: 10.1172/JCI1582.
3 Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.Cardiovasc Res. 2010 Jul 1;87(1):50-9. doi: 10.1093/cvr/cvq007. Epub 2010 Jan 15.
4 Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?.J Am Coll Cardiol. 2010 Jun 8;55(23):2570-6. doi: 10.1016/j.jacc.2009.12.063.