Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE0K82S)

DME Name Nitroreductase (NTR)
Synonyms
FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; AAK29_19565; AAP89_17340; ABO94_21460; AF480_20870; AF488_23150; AF489_23340; AIC76_20195; AU613_12225; AXR84_20760; AXU58_04975; C2253_16765; CD48_22070; CE87_20375; CET98_22760; CQG18_18555; CVR97_26810; D4369_19420; D4380_20855; D4401_19160; D4E62_20230; D6360_18430; D7F20_19765; D7H43_20545; DJ388_15780; DKJ11_20120; DKU57_16540; DLM31_17395; DNV30_18555; DO698_18905; DOJ90_20570; DOQ88_18330; DPJ93_20300; DQ848_17880; DRM14_15155; DSF69_18065; DSR36_20995; DUW48_14845; EBO41_17185; EBP31_19365; EGU67_18695; EHB24_16995; EHC98_18885; EIW53_20245; GW08_19510; LZ63_23085; NG18_18155; NU83_21515; QA89_14925; QB40_21055; QD15_17380; RJ78_20865; SAMEA4398682_04794; SBOV39431; Y934_22205; YG50_14570; YI33_18440; YR17_18395; ZA53_16690; ZB89_19155
Gene Name yieF
UniProt ID
A0A5K1UB29_SALTM
INTEDE ID
DME1968
EC Number EC: 1.5.1.39
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage Species: Salmonella typhimurium
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella typhimurium

Subspecies: Salmonella typhimurium subsp. enterica serovar Typhimurium
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKGARMSETLNVVTLLGSLRKGSFNGMVARTLPKVAPAGMTVSPLPSIGDIPLYDADIQ
QEEGFPASVEALAEQIRNADGVVIVTPEYNYSVPGGLKNAIDWLSRLPEQPLAGKPVLIQ
TSSMGAIGGARCQYHLRQILVFLDAMVMNKPEFMGGVIQNKVDPQTGEVVDQGTLDHLTG
QLTAFGEFIQRVKA
Function This enzyme catalyzes the reduction of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
3 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [2], [3]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [2], [3]
2 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mononitrophenol DM4QO9G Discovery agent N.A. Investigative [2], [3]
Nitrobenzoate DM6FVHC Discovery agent N.A. Investigative [2], [3]

References

1 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
2 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
3 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter