General Information of DME (ID: DE0K82S)

DME Name Nitroreductase (NTR) DME Info
UniProt ID
A0A5K1UB29_SALTM
Gene Name yieF

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
3 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [2], [3]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [2], [3]
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2 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mononitrophenol DM4QO9G Discovery agent N.A. Investigative [2], [3]
Nitrobenzoate DM6FVHC Discovery agent N.A. Investigative [2], [3]
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Molecule Interaction Atlas

References

1 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
2 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
3 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter