Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2AZTG)

DME Name	Endoglucanase Y (EGY)
Synonyms	Endo-1,4-beta-glucanase Y; SGNH_hydro domain-containing protein Y; Cellulase Y; EGY; CBG24_05650
Gene Name	EGY
UniProt ID	A0A256VAC0_LACRE
INTEDE ID	DME1642
EC Number	EC: 3.2.1.136 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.136
Lineage	Species: Lactobacillus johnsonii Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus johnsonii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKKYQPTDLIKFASRTGRWTIKKLDNSPTLYTTNLGSYLRFKVSDAKKCQITVLPNQNSL SPSQVFAFRIDGGKWQRAQASLEKIDIPLDSTLHTIEIMAAGNTDIDEVWQGNEGFAIKN IYLDRGEITAAPQRPLINFIGDSITAGCWVVGNHPAADYRPETNYAGICADLLNVDSVRI AYSAGGVLRPATGGVPTADVFLGKIDNQTLWTPNHPDLNVINLGVNDRRFPLTQFIAAFD LFIQQVKLTFPHTPLAIIIPFSQTFASAIRTIATKHDCSIIETKTWHHSFTDGLHPDQAG AINEGKMLAQALQPLLPQFSVQ
Function	This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkages.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

5 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[1]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[1]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[1]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.