Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAN5EW)

• DME Name: Nitroreductase (NTR)
• Synonyms: FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; nfsB; nfsI
• Gene Name: nfsB
• UniProt ID: NFSB_ENTCL
• INTEDE ID: DME1247
• EC Number:
  EC: 1.5.1.39
  Oxidoreductase
  CH-NH donor oxidoreductase
  NAD/NADP acceptor oxidoreductase
  EC: 1.5.1.39
• Lineage:
  Species: Enterobacter cloacae
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Enterobacter
  Species: Enterobacter cloacae
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
  AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG
  RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE
  KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
• Function: This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metronidazole	DMTIVEN	Amoebiasis	1A36	Approved	[1]
Secnidazole	DMJ18YL	Amoebiasis	1A36	Approved	[1]
Tindamax	DM3OWT4	Bacterial infection	1A00-1C4Z	Approved	[1]

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	Trypanosomiasis	1D51-1F53	Phase 1	[1]

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzoquinone	DMNBA0G	Discovery agent	N.A.	Investigative	[1]

References

• [1] Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.