Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAN5EW)
DME Name | Nitroreductase (NTR) | ||||
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Synonyms | FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; nfsB; nfsI | ||||
Gene Name | nfsB | ||||
UniProt ID | |||||
INTEDE ID | |||||
3D Structure | |||||
EC Number | EC: 1.5.1.39 | ||||
Lineage | Species: Enterobacter cloacae | ||||
Tissue Distribution | Primarily distributed in human gut. | ||||
Sequence |
MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC |
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Function | This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds. | ||||
Molecular Interaction Atlas (MIA) of This DME
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||
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3 Approved Drug(s) Metabolized by This DME
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1 Clinical Trial Drug(s) Metabolized by This DME
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1 Investigative Drug(s) Metabolized by This DME
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