General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAN5EW)

DME Name Nitroreductase (NTR)
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; nfsB; nfsI
Gene Name nfsB
UniProt ID
NFSB_ENTCL
INTEDE ID
DME1247
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 1.5.1.39
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage Species: Enterobacter cloacae
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Tissue Distribution Primarily distributed in human gut.
Sequence
MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG
RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE
KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
3 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metronidazole DMTIVEN Abscess Approved [1]
Secnidazole DMJ18YL Amoebiasis 1A36 Approved [1]
Tindamax DM3OWT4 Bacterial infection 1A00-1C4Z Approved [1]
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
AI3-23606 DMHMT49 N. A. N. A. Phase 1 [1]
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
BENZOQUINONE DMNBA0G Discovery agent N.A. Investigative [1]

References

1 Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.