Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEGLTNR)

DME Name Sulfide-quinone reductase (SQR)
Synonyms Sulfide:quinone oxidoreductase; Sulfide dehydrogenase-like; AFE_1792; SQR
Gene Name SQR
UniProt ID
SQRD_ACIF2
INTEDE ID
DME1797
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 1.8.5.4
Oxidoreductase
Sulfur donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.8.5.4
Lineage Species: Acidithiobacillus ferrooxidans
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Acidithiobacillia
Order: Acidithiobacillales
Family: Acidithiobacillaceae
Genus: Acidithiobacillus
Species: Acidithiobacillus ferrooxidans
Tissue Distribution Primarily distributed in human gut.
Sequence
MAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPWVGVGWKERDDIAF
PIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFENVPGSDPH
EGPVQSICTVDHAERAFAEYQALLREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGM
RDKIPSFTFITSEPYIGHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQ
VDEKGETIKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANIFAA
GIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQTMGTWNAVCFADM
GDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKYFIRKMKMGVSEPFYEKVLFKMMG
ITRLKEEDTHRKAS
Function This enzyme contains FAD, and in some organisms it catalyses the formation of sulfur globules. And it can catalyze the oxidation of hydrogen sulfide, with the help of a quinone.
KEGG Pathway
Sulfur metabolism (afr00920 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [1]
BENZOQUINONE DMNBA0G Discovery agent N.A. Investigative [1]

References

1 The quinone-binding site of Acidithiobacillus ferrooxidans sulfide: quinone oxidoreductase controls both sulfide oxidation and quinone reduction. Biochem Cell Biol. 2016 Apr;94(2):159-66.