Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEP7E8X)

DME Name Sulfotransferase 1A3 (SULT1A3)
Synonyms
Sulfotransferase family cytosolic 1A member 3; Aryl sulfotransferase 1A3; Aryl sulfotransferase 3; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Monoamine-preferring sulfotransferase; TL-PST; Thermolabile phenol sulfotransferase; HAST3; M-PST; ST1A3; STM; SULT1A3
Gene Name SULT1A3
UniProt ID
ST1A3_HUMAN
INTEDE ID
DME0063
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
6818
EC Number EC: 2.8.2.1
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.1
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDM
IYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLD
QKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNY
TTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
Function
This enzyme utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
KEGG Pathway
Chemical carcinogenesis (hsa05204 )
Reactome Pathway
XBP1(S) activates chaperone genes (R-HSA-381038 )
Cytosolic sulfonation of small molecules (R-HSA-156584 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rotigotine DMP7X6Q N. A. N. A. Approved [1]
Salbutamol DMN9CWF Acute asthma CA23 Approved [2]

References

1 Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
2 SULT 1A3 single-nucleotide polymorphism and the single dose pharmacokinetics of inhaled salbutamol enantiomers: are some athletes at risk of higher urine levels? Drug Test Anal. 2015 Feb;7(2):109-13.