Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZ1H4L)

DME Name	Cytochrome P450 MEG (cyp106)
Synonyms	Steroid 15-beta-hydroxylase; Steroid 15-beta-monooxygenase; Cytochrome P450(MEG); P450(MEG); cyp106A2
Gene Name	cyp106A2
UniProt ID	CPXM_BACME
INTEDE ID	DME1072
EC Number	EC: 1.14.15.8 Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.8
Lineage	Species: Bacillus megaterium Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus megaterium Subspecies: Bacillus megaterium ATCC 13368
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKEVIAVKEITRFKTRTEEFSPYAWCKRMLENDPVSYHEGTDTWNVFKYEDVKRVLSDYK HFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQ EIADELIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSKDRLLFKKWVDTLFLPFDREK QEEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLI LGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLVPQAVEEMLRFRFNLIKLDRTVKE DNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKKHLTFGNGPHFCLGAPL ARLEAKIALTAFLKKFKHIEAVPSFQLEENLTDSATGQTLTSLPLKASRM
Function	This enzyme has the capacity to hydroxylate certain steroids in the 15-beta position, and it also hydroxylates progesterone in the 11-alpha and 9-beta position.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[2], [3]
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References

1	Engineering of CYP106A2 for steroid 9alpha- and 6beta-hydroxylation. Steroids. 2017 Apr;120:41-48.
2	acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
3	A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.